Philip M. Hopkins (Avtor), Peter J. Cooke (Avtor), Russel C. Clarke (Avtor), Anne Berit Guttormsen (Avtor), Peter R. Platt (Avtor), Pascale Dewachter (Avtor), D. Ebo (Avtor), Tomaz Garcez (Avtor), Lene Heise Garvey (Avtor), David L. Hepner (Avtor), Peter Kopač (Avtor)

Povzetek

Background: Grading schemes for severity of suspected allergic reactions have been applied to the perioperative setting, but there is no scoring system that estimates the likelihood that the reaction is an immediate hypersensitivity reaction. Such a score would be useful in evaluating current and proposed tests for the diagnosis of suspected perioperative immediate hypersensitivity reactions and culprit agents. Methods: We conducted a Delphi consensus process involving a panel of 25 international multidisciplinary experts in suspected perioperative allergy. Items were ranked according to appropriateness (on a scale of 1-9) and consensus, which informed development of a clinical scoring system. The scoring system was assessed by comparing scores generated for a series of clinical scenarios against ratings of panel members. Supplementary scores for mast cell tryptase were generated. Results: Two rounds of the Delphi process achieved stopping criteria for all statements. From an initial 60 statements, 43 were rated appropriate (median score 7 or more) and met agreement criteria (disagreement index <0.5); these were used in the clinical scoring system. The rating of clinical scenarios supported the validity of the scoring system. Although there was variability in the interpretation of changes in mast cell tryptase by the panel, we were able to include supplementary scores for mast cell tryptase. Conclusion: We used a robust consensus development process to devise a clinical scoring system for suspected perioperative immediate hypersensitivity reactions. This will enable objectivity and uniformity in the assessment of the sensitivity of diagnostic tests.

Ključne besede

alergy and immunology;anesthesia;anaphylaxis;drug hypersensitivity;drug-related side effects and adverse reactions;perioperative period;surgery;operative surgical procedures;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Založnik: Elsevier
UDK: 616-097
COBISS: 2048509297 Povezava se bo odprla v novem oknu
ISSN: 1471-6771
Matična publikacija: British journal of anaesthesia
Št. ogledov: 791
Št. prenosov: 198
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarne ključne besede: Allergy and immunology;Anesthesia;Anaphylaxis;Drug hypersensitivity;Drug-related side effects and adverse reactions;Perioperative period;Surgery;Surgical procedures, operative;Alergija in imunologija;Anestezija;Anafilaksija;Preobčutljivost za zdravila;Stranski in škodljivi učinki zdravil;Perioperativno obdobje;Kirurgija;Operativni kirurški postopki;
Komentar vira: Soavtor iz Slovenije: P. Kopac; Nasl. z nasl. zaslona; Opis vira z dne 4. 6. 2019;
Strani: str. e29-e37
Letnik: ǂVol. ǂ123
Zvezek: ǂiss. ǂ1
Čas izdaje: Jul. 2019
DOI: 10.1016/j.bja.2019.02.029
ID: 12066577