Fazlurrahman Khan (Author), Dung Thuy Nguyen Pham (Author), Nazia Tabassum (Author), Sandra Oloketuyi (Author), Young-Mog Kim (Author)

Abstract

Persister cells are transiently antibiotic-tolerant and dormant subpopulations that are produced to escape the effects of antibiotics within biofilms or planktonic cell populations. Persister cells are of high clinical importance due to their tolerance to antimicrobial agents and subsequent failure in antibiotic treatments. Understanding persister cell formation mechanisms is therefore highly important for developing effective therapeutic strategies against pathogenic bacterial persisters. Several anti-persister compounds have been previously identified via isolation from natural resources or chemical synthesis. Furthermore, a combination of these compounds with antibiotics or non-antibiotic drugs also allows action on multiple targets while reducing the administration frequency. Here, we present a comprehensive overview of the clinical importance and formation mechanisms of persister cells as well as the current treatment strategies against persister cell formations in chronic infections.

Keywords

biofilm;anti-persister agents;persister cells;pathogenic bacteria;chronic infections;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UNG - University of Nova Gorica
UDC: 579
COBISS: 47104259 Link will open in a new window
ISSN: 1040-841X
Views: 1754
Downloads: 0
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Other data

URN: URN:SI:UNG
Type (COBISS): Not categorized
Pages: str. 665-688
Volume: ǂVol. ǂ46
Issue: ǂno. ǂ6
Chronology: 2020
DOI: 10.1080/1040841X.2020.1822278
ID: 12384989