antibiofilm drugs against pathogenic bacteria
Fazlurrahman Khan (Avtor), Dung Thuy Nguyen Pham (Avtor), Sandra Oloketuyi (Avtor), Panchanathan Manivasagan (Avtor), Junghwan Oh (Avtor), Young-Mog Kim (Avtor)

Povzetek

Biofilm formed by several pathogenic bacteria results in the development of resistance against antimicrobial compounds. The polymeric materials present in the biofilm architecture hinder the entry of antimicrobial compounds through the surface of bacterial cells which are embedded as well as enclosed beneath the biofilm matrix. Recent and past studies explored the alternative approaches to inhibit the formation of biofilm by different agents isolated from plants, animals, and microbes. Among these agents, chitosan and its derivatives have got more attention due to their properties such as biodegradability, biocompatibility, non-allergenic and non-toxicity. Recent researches have focused on employing chitosan and its derivatives as effective agents to inhibit biofilm formation and attenuate virulence properties by various pathogenic bacteria. Such antibiofilm activity of chitosan and its derivatives can be further enhanced by conjugation with a wide range of bioactive compounds. The present review describes the antibiofilm properties of chitosan and its derivatives against the pathogenic bacteria. This review also summarizes the mechanisms of biofilm inhibition exhibited by these molecules. The knowledge of the antibiofilm activities of chitosan and its derivatives as well as their underlying mechanisms provides essential insights for widening their applications in the future.

Ključne besede

antibiofilm;biofilm inhibition;chitosan;chitosan derivatives;pathogenic bacteria;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UNG - Univerza v Novi Gorici
UDK: 579
COBISS: 47102979 Povezava se bo odprla v novem oknu
ISSN: 0927-7765
Št. ogledov: 1682
Št. prenosov: 0
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

URN: URN:SI:UNG
Vrsta dela (COBISS): Delo ni kategorizirano
Strani: str. 1-16
Zvezek: ǂVol. ǂ185
Čas izdaje: 2020
DOI: 10.1016/j.colsurfb.2019.110627
ID: 12384990