Fazlurrahman Khan (Avtor), Dung Thuy Nguyen Pham (Avtor), Nazia Tabassum (Avtor), Sandra Oloketuyi (Avtor), Young-Mog Kim (Avtor)

Povzetek

Persister cells are transiently antibiotic-tolerant and dormant subpopulations that are produced to escape the effects of antibiotics within biofilms or planktonic cell populations. Persister cells are of high clinical importance due to their tolerance to antimicrobial agents and subsequent failure in antibiotic treatments. Understanding persister cell formation mechanisms is therefore highly important for developing effective therapeutic strategies against pathogenic bacterial persisters. Several anti-persister compounds have been previously identified via isolation from natural resources or chemical synthesis. Furthermore, a combination of these compounds with antibiotics or non-antibiotic drugs also allows action on multiple targets while reducing the administration frequency. Here, we present a comprehensive overview of the clinical importance and formation mechanisms of persister cells as well as the current treatment strategies against persister cell formations in chronic infections.

Ključne besede

biofilm;anti-persister agents;persister cells;pathogenic bacteria;chronic infections;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UNG - Univerza v Novi Gorici
UDK: 579
COBISS: 47104259 Povezava se bo odprla v novem oknu
ISSN: 1040-841X
Št. ogledov: 1754
Št. prenosov: 0
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

URN: URN:SI:UNG
Vrsta dela (COBISS): Delo ni kategorizirano
Strani: str. 665-688
Letnik: ǂVol. ǂ46
Zvezek: ǂno. ǂ6
Čas izdaje: 2020
DOI: 10.1080/1040841X.2020.1822278
ID: 12384989