ǂa ǂreview
Fazlurrahman Khan (Author), Nazia Tabassum (Author), Dung Thuy Nguyen Pham (Author), Sandra Oloketuyi (Author), Young-Mog Kim (Author)

Abstract

The initial colonization of the host organism by commensal, probiotic, and pathogenic Escherichia coli strains is an important step in the development of infections and biofilms. Sensing and colonization of host cell surfaces are governed by flagellar and fimbriae/pili appendages, respectively. Biofilm formation confers great advantages on pathogenic E. coli cells such as protection against the host immune system, antimicrobial agents, and several environmental stress factors. The transition from planktonic to sessile physiological states involves several signaling cascades and factors responsible for the regulation of flagellar motility in E. coli cells. These regulatory factors have thus become important targets to control pathogenicity. Hence, attenuation of flagellar motility is considered a potential therapy against pathogenic E. coli. The present review describes signaling pathways and proteins involved in direct or indirect regulation of flagellar motility. Furthermore, application strategies for antimotility natural or synthetic compounds are discussed also.

Keywords

biofilm formation;Escherichia coli;inhibition;motility;pathogenesis;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UNG - University of Nova Gorica
UDC: 579
COBISS: 47104003 Link will open in a new window
ISSN: 0892-7014
Views: 2436
Downloads: 0
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Other data

URN: URN:SI:UNG
Type (COBISS): Not categorized
Pages: str. 889-908
Volume: ǂVol. ǂ36
Issue: ǂno. ǂ8
Chronology: 2020
DOI: 10.1080/08927014.2020.1826939
ID: 12384992