ǂa ǂreview
Fazlurrahman Khan (Avtor), Nazia Tabassum (Avtor), Dung Thuy Nguyen Pham (Avtor), Sandra Oloketuyi (Avtor), Young-Mog Kim (Avtor)

Povzetek

The initial colonization of the host organism by commensal, probiotic, and pathogenic Escherichia coli strains is an important step in the development of infections and biofilms. Sensing and colonization of host cell surfaces are governed by flagellar and fimbriae/pili appendages, respectively. Biofilm formation confers great advantages on pathogenic E. coli cells such as protection against the host immune system, antimicrobial agents, and several environmental stress factors. The transition from planktonic to sessile physiological states involves several signaling cascades and factors responsible for the regulation of flagellar motility in E. coli cells. These regulatory factors have thus become important targets to control pathogenicity. Hence, attenuation of flagellar motility is considered a potential therapy against pathogenic E. coli. The present review describes signaling pathways and proteins involved in direct or indirect regulation of flagellar motility. Furthermore, application strategies for antimotility natural or synthetic compounds are discussed also.

Ključne besede

biofilm formation;Escherichia coli;inhibition;motility;pathogenesis;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UNG - Univerza v Novi Gorici
UDK: 579
COBISS: 47104003 Povezava se bo odprla v novem oknu
ISSN: 0892-7014
Št. ogledov: 2436
Št. prenosov: 0
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

URN: URN:SI:UNG
Vrsta dela (COBISS): Delo ni kategorizirano
Strani: str. 889-908
Letnik: ǂVol. ǂ36
Zvezek: ǂno. ǂ8
Čas izdaje: 2020
DOI: 10.1080/08927014.2020.1826939
ID: 12384992