library platforms and diversification strategies
Krištof Bozovičar (Author), Tomaž Bratkovič (Author)

Abstract

Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients, versatile tools in drug discovery, and for drug delivery. They find themselves at the crossroads of small molecules and proteins, possessing favorable tissue penetration and the capability to engage into specific and high-affinity interactions with endogenous receptors. One of the commonly employed approaches in peptide discovery and design is to screen combinatorial libraries, comprising a myriad of peptide variants of either chemical or biological origin. In this review, we focus mainly on recombinant peptide libraries, discussing different platforms for their display or expression, and various diversification strategies for library design. We take a look at well-established technologies as well as new developments and future directions.

Keywords

kombinatorna knjižnica;peptidna knjižnica;peptide;combinatorial library;library design;screening;mutagenesis;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL FFA - Faculty of Pharmacy
Publisher: MDPI
UDC: 543.645.6:579
COBISS: 4866673 Link will open in a new window
ISSN: 1422-0067
Views: 270
Downloads: 126
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: Slovenian
Secondary keywords: Peptidi;Mutageneza;
Type (COBISS): Article
Pages: str. 1-31
Volume: ǂVol. ǂ21
Issue: ǂno. ǂ1
Chronology: 2020
DOI: 10.3390/ijms21010215
ID: 12642515