library platforms and diversification strategies
Krištof Bozovičar (Avtor), Tomaž Bratkovič (Avtor)

Povzetek

Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients, versatile tools in drug discovery, and for drug delivery. They find themselves at the crossroads of small molecules and proteins, possessing favorable tissue penetration and the capability to engage into specific and high-affinity interactions with endogenous receptors. One of the commonly employed approaches in peptide discovery and design is to screen combinatorial libraries, comprising a myriad of peptide variants of either chemical or biological origin. In this review, we focus mainly on recombinant peptide libraries, discussing different platforms for their display or expression, and various diversification strategies for library design. We take a look at well-established technologies as well as new developments and future directions.

Ključne besede

kombinatorna knjižnica;peptidna knjižnica;peptide;combinatorial library;library design;screening;mutagenesis;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL FFA - Fakulteta za farmacijo
Založnik: MDPI
UDK: 543.645.6:579
COBISS: 4866673 Povezava se bo odprla v novem oknu
ISSN: 1422-0067
Št. ogledov: 270
Št. prenosov: 126
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: Peptidi;Mutageneza;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-31
Letnik: ǂVol. ǂ21
Zvezek: ǂno. ǂ1
Čas izdaje: 2020
DOI: 10.3390/ijms21010215
ID: 12642515