Sinteza funkcionaliziranih magnetnih nanodelcev z visokoenergetskim mlinom za uporabo v biomedicini

diplomsko delo univerzitetnega študijskega programa I. stopnje

Lana Embreuš (Author), Irena Ban (Mentor), Janja Stergar (Co-mentor)

Abstract

Diplomsko delo predstavlja sintezo magnetnih nanodelcev z mletjem prahu niklja in bakra v visokoenergetskem planetarnem mlinu. Med eksperimentalnim delom smo spreminjali različne parametre, in sicer čas mletja, sestavo in čas prepihovanja mlevne posodice. Naš namen je bil raziskati, kako ti parametri vplivajo na Curiejevo temperaturo (TC) in doseči takšno, ki bi bila znotraj terapevtskega območja uporabe v magnetni hipertermiji. Sintetizirali smo NiCu nanodelce različnih sestav v inertni atmosferi argona. Začeli smo z mletjem enake sestave različno dolgo in najboljši rezultat dobili s časom mletja 5,5 h. Vsem vzorcem smo z modificirano termično analizo (TGA) izmerili TC, najbolj optimalnega pa okarakterizirali še z rentgensko praškovno difrakcijo (RTG), ki je potrdila, da je nastala zlitina z velikostjo nanodelcev okrog 10 nm. Na začetku smo določili čas prepihovanja z argonom 10 min, vendar smo z mletjem dokazali, da bi bilo za zagotovitev inertne atmosfere dovolj že 5 min prepihovanja. Zanimalo nas je, kako se spreminja TC, če spremenimo sestavo, čas mletja pa ostane konstanten. Rezultati kažejo, da se z večanjem vsebnosti niklja TC viša, dokazali pa smo tudi, da vse sestave z vsebnostjo niklja med 72,5 % in 75 % doprinesejo k TC, ki se nahaja v območju primernem za magnetno hipertermijo.

Keywords

magnetni nanodelci;NiCu;mehansko mletje;Curiejeva temperatura;biomedicinske aplikacije;magnetna hipertermija;diplomske naloge;

Data

Language:	Slovenian
Year of publishing:	2022
Typology:	2.11 - Undergraduate Thesis
Organization:	UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher:	[L. Emreuš]
UDC:	620.179.141:620.3(043.2)
COBISS:	121392387
Views:	18
Downloads:	4
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Synthesis of functionalized magnetic nanoparticles by a high-energy mill for use in biomedicine
Secondary abstract:	In this thesis, we present the synthesis of magnetic nanoparticles by milling nickel and copper powders in a high-energy planetary ball mill. During the experimental work we changed various parameters, namely milling time, composition and purging time of the grinding bowl. Our aim was to investigate how these parameters affect the Curie temperature (TC) and achieve a temperature within the application range of magnetic hyperthermia. We synthesized NiCu nanoparticles of different compositions in an inert argon atmosphere. We started with the milling of the same composition for different time periods and obtained the best result with a milling time of 5.5 h. The TC was measured for all samples by modified thermal analysis (TGA), and the most optimal one was characterized by X-ray powder diffraction (XRD), which confirmed that a true alloy with a particle size of 10 nm was formed. Originally, we had specified an argon purging time of 10 minutes, but we proved by milling that 5 minutes of purging would be sufficient to ensure an inert atmosphere. We were interested in seeing how the TC changed as we changed the composition and kept the milling time constant. The results show that as the nickel content increases, the TC increases, and we also showed that all compositions with nickel content between 72.5 % and 75 % contribute to the TC, which is in the range suitable for magnetic hyperthermia.
Secondary keywords:	magnetic nanoparticles;NiCu;mechanical milling;Curie temperature;biomedical applications;magnetic hyperthermia;
Type (COBISS):	Bachelor thesis/paper
Thesis comment:	Univ. v Mariboru, Fak. za kemijo in kemijsko tehnologijo
Pages:	1 spletni vir (1 datoteka PDF (VIII, 27 f.))
ID:	15742532