Language: | Slovenian |
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Year of publishing: | 2022 |
Typology: | 2.11 - Undergraduate Thesis |
Organization: | UL FKKT - Faculty of Chemistry and Chemical Technology |
Publisher: | [P. Kumar] |
UDC: | 547.78(043.2) |
COBISS: | 116120067 |
Views: | 93 |
Downloads: | 41 |
Average score: | 0 (0 votes) |
Metadata: |
Secondary language: | English |
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Secondary title: | Synthesis of some ethyl 1-aryl-5-hydroxy-1H-pyrazole-4-carboxylates as inhibitors of dihydroorotate dehydrogenase. |
Secondary abstract: | Pyrazole and its derivatives are an interesting group of heterocyclic compounds as they exhibit diverse biological activities. Consequently, they have received a great deal of attention from the scientific community. In this thesis, I have undertaken the synthesis of four ethyl 1-aryl-5-hydroxy-1H-pyrazole-4-carboxylates, which are inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). They were synthesized according to the procedure described in the literature. The synthesis of the pyrazole ring was based on the cyclocondensation of the corresponding hydrazine with diethyl 2-(ethoxymethylene)malonate. Compound 3a was synthesized according to the one-step procedure described in the literature. Compounds 3b and 3c were obtained by a slight modification of the literature procedure under basic conditions. Compound 3d was synthesized using EtOH and Et3N in a ratio of 3:1. All products were characterized by 1H NMR and IR spectroscopy. The synthesized inhibitors were tested by enzymatic assays at the Chair of Biochemistry of UL FCCT. |
Secondary keywords: | malaria;pyrazoles;cyclocondensation;PfDHODH inhibitors;heterocyclic compounds;Pirazoli;Univerzitetna in visokošolska dela; |
Type (COBISS): | Bachelor thesis/paper |
Study programme: | 1000373 |
Embargo end date (OpenAIRE): | 1970-01-01 |
Thesis comment: | Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemija |
Pages: | 37 str. |
ID: | 15795577 |