diplomsko delo
Vuk Martinović (Author), Jurij Svete (Mentor)

Abstract

Preiskovana je bila derivatizacija 6-aminokaprojske kisline, s pripajanjem izolevcinskega estra na Cbz-zaščiteno 6-aminokaprojsko kislino. Peptid je bil sintetiziran iz izhodnih spojin z uporabo različnih pripajalnih reagentov - CDI, EDC in EEDQ. Kot najboljši reagent glede na čistoto produkta se je iskazal EDC; najslabši za to reakcijo pa je bil EEDQ. Dobljeni peptid je bil nato odščiten na N-koncu, aminska skupina pa acilirana s 4-pentinojsko kislino z uporabo EDC reagenta. Sinteza je bila uspešna, kar je bilo razvidno iz NMR spektrov končne spojine. Končni derivat 6-aminokaprojske kisline je N-konec elektrofilne sonde, katere preostanek je del diplomskih del drugih kolegov. Sinteza te elektrofilne sonde ne sovpada v obseg tega diplomskega dela.

Keywords

peptidna kemija;6-aminokaprojska kislina;aktivacijski reagenti;zaščita aminokislin;diplomska dela;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher: [V. Martinović]
UDC: 547.466(043.2)
COBISS: 126230275 Link will open in a new window
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Downloads: 9
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Other data

Secondary language: English
Secondary title: Derivatization of 6-aminocaproic acid
Secondary abstract: The derivatization of 6-aminocaproic acid was investigated by coupling the isoleucine ester with Cbz-protected 6-aminocaproic acid. The peptide was synthesized from the starting compounds using various coupling reagents - CDI, EDC and EEDQ. EDC proved to be the best reagent, yielding the purest product; the worst for this reaction, however, was EEDQ. To the resulting peptide, 4-pentynoic acid was additionally attached using the EDC reagent. The synthesis was successful as confirmed by the NMR spectra of the final compound. The final derivative of 6-aminocaproic acid is the N-terminus of the electrophilic probe, in which the remainder of the probe is a part of the thesis of other colleagues. The synthesis of this electrophilic probe does not fall within the scope of this task.
Secondary keywords: peptides;coupling reagents;amino acid protection;Peptidi;Univerzitetna in visokošolska dela;
Type (COBISS): Bachelor thesis/paper
Study programme: 1000373
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemija
Pages: 38 str.
ID: 16382186