diplomsko delo
Ivo Godina (Author), Peter Bohinc (Reviewer), Klemen Bohinc (Mentor), Anže Abram (Co-mentor), Franc Rojko (Co-mentor)

Abstract

Uvod: V primeru popolnoma brezzobe čeljusti je ena izmed najpogostejših zobnih nadomestkov totalna proteza, ki je izdelana iz akrilatne smole ter konfekcijskih zob. Pacientu povrne lep videz, nasmeh ter možnost izvajanja fizioloških funkcij, kot so žvečenje, požiranje ter govor, obenem pa tudi blagodejno vpliva na psihofizično počutje pacienta. Prednost uporabe naprednih materialov za zobne nadomestke se kaže v boljših mehanskih lastnostih, trajnosti, odpornosti proti koroziji in biokompatibilnosti. Številne raziskave so pokazale učinke in napredek z uporabo nanokompozitov, ki so ugodno vpivali na mehanske in fiziološke lastnosti materiala. Namen: Namen diplomskega dela je ugotoviti, kako se z dodatkom TiO2 nanodelcev k PMMA spremenijo nekatere mehanske lastnosti (mejni kot, zeta potencial, hrapavost, barva) ter adhezija bakterije Streptococcus mutans. Metode dela: Uvodni teoretični del je napisan po literaturnem pregledu predvsem tujih strokovnih člankov iz strokovnih baz, kot so PubMed, GoogleScholar in Web of Science. V praktičnem delu smo izdelali akrilatne ploščice z različnimi vsebnostmi TiO2 nanodelcev (0 %, 1 %, 5 %, 10 %, 20 %), katerim smo izmerili hrapavost na Zdravstveni fakulteti (Univerza v Ljubljani), zeta potencial na Inštitutu Jožef Stefan, mejni kot na Zdravstveni fakulteti (Univerza v Ljubljani), adhezijo bakterij na Inštitutu Jožef Stefan, izbrane mehanske lastnosti materiala na Zavodu za gradbeništvo Slovenije in barvo na Biotehniški fakulteti (Univerza v Ljubljani). Rezultati: Preizkušance smo pripravili v zobnem laboratoriju Franca Rojka. Meritve in preizkuse smo opravili na Zdravstveni fakulteti (Univerza v Ljubljani), Inštitutu Jožef Stefan, Zavodu za Gradbeništvo Slovenije in Biotehniški fakulteti (Univerze v Ljubljani). Največjo hrapavost, zeta potencial in mejni kot smo izmerili na PMMA + 1 % TiO2. Čisti PMMA in PMMA + 1 % TiO2 sta hidrofobna, preizkušanci s 5 %, 10 % in 20 % TiO2 imajo hidrofilno površino. Dodatek TiO2 k PMMA je zmanjšal odstotek pritrjenih bakterij S. mutans na materialu v primerjavi s čistim PMMA. Z večanjem koncentracije TiO2 se je enoosna natezna trdnost zmanjševala. Z dodatkom TiO2 k PMMA je material dobil svetlejšo barvo, manj rdečkastih in modrikastih tonov. Razprava in zaključek: Na podlagi dobljenih podatkov lahko povzamemo, da PMMA modificiran s TiO2 nanodelci ni primeren za izdelavo protetičnih nadomestkov, saj ne izpolnjuje barvnih zahtev. Hrapavost, zeta potencial in hidrofobnost pomembno vplivajo na pritrjevanje bakterij. Glavna klinična pomanjkljivost čistega PMMA je slabo antibakterijsko delovanje. Za dodatek TiO2 v PMMA pri izdelavi protetičnih nadomestkov bi bilo potrebno najti ustrezno rešitev za barvno ustreznost.

Keywords

diplomska dela;laboratorijska zobna protetika;PMMA;TiO2;bakterijska adhezija;mehanske lastnosti;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL ZF - University College of Health Studies
Publisher: [I. Godina]
UDC: 616.31
COBISS: 124509187 Link will open in a new window
Views: 6
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Other data

Secondary language: English
Secondary title: Effect of TiO2 addition on the mechanical properties of PMMA and adhesion of Streptococcus mutans
Secondary abstract: Introduction: In the case of a completely edentulous jaw, one of the most common tooth replacements is a total denture, which is made of acrylic resin and prefabricated teeth. It restores the patient's appearance, smile and the ability to perform physiological functions such as chewing, swallowing and speech, while also having a beneficial effect on the patient's psycho-physical well-being. The advantage of using advanced denture materials is reflected in better mechanical properties (strength, durability, corrosion resistance, biocompatibility). A number of studies have shown the effects and progress made using nanocomposites that have favourably influenced the mechanical and physiological properties of the material, including TiO2. Purpose: The aim of this thesis is to investigate how the addition of TiO2 nanoparticles to PMMA changes some mechanical properties (contact angle, zeta potential, roughness, colour, elastic properties) and the adhesion of Streptococcus mutans. Methods: The introductory theoretical part is written after a literature review of mainly foreign peer-reviewed articles from databases such as PubMed, GoogleScholar and Web of Science. In the practical part, under the supervision of the mentor, we made acrylate plates with different TiO2 nanoparticle contents (0%, 1%, 5%), which were then measured for the limiting angle at the Faculty of Health Sciences (University of Ljubljana), for the colour at the private dental laboratory Franc Rojko, and for the roughness, zeta potential and bacterial adhesion at the Jožef Stefan Institute. We also measured the elasticity of the material at the Slovenian national building and civil engineering institute. Results: The test subjects were prepared in the dental laboratory of Franc Rojko. Measurements and tests were carried out at the Faculty of Health Sciences, University of Ljubljana, the Jožef Stefan Institute, the Building Research Institute of Slovenia and the Faculty of Biotechnology, University of Ljubljana. The maximum roughness, zeta potential and contact angle were measured on PMMA + 1% TiO2. Pure PMMA and PMMA + 1 % TiO2 are hydrophobic, while the 5 %, 10 % and 20 % TiO2 test specimens have a hydrophilic surface. The addition of TiO2 to PMMA reduced the percentage of attached S. mutans bacteria on the material compared to pure PMMA. The uniaxial tensile strength decreased with increasing TiO2 concentration. The addition of TiO2 to PMMA resulted in a brighter colour, less reddish and bluish tones. Discussion and conclusion: Based on the data obtained, it can be summarised that PMMA modified with TiO2 nanoparticles is not suitable for the fabrication of prosthetic restorations as it does not meet the colour requirements. Roughness, zeta potential and hydrophobicity have a significant effect on bacterial attachment. The main clinical drawback of pure PMMA is its poor antibacterial activity. For the use of TiO2 in the fabrication of prosthetic restorations, a suitable solution for colour matching would need to be found.
Secondary keywords: diploma theses;laboratory dental prosthetics;PMMA;TiO2;bacterial adhesion;mechanical properties;
Type (COBISS): Bachelor thesis/paper
Study programme: 0
Thesis comment: Univ. v Ljubljani, Zdravstvena fak., Oddelek za protetiko
Pages: 37 str., [10] str. pril.
ID: 16671155