Mojca Zupanc (Author), Jure Zevnik (Author), Arijana Filipić (Author), Ion Gutierrez-Aguirre (Author), Meta Ješelnik (Author), Tamara Košir (Author), Jernej Ortar (Author), Matevž Dular (Author), Martin Petkovšek (Author)

Abstract

The COVID -19 pandemic reminded us that we need better contingency plans to prevent the spread of infectious agents and the occurrence of epidemics or pandemics. Although the transmissibility of SARS-CoV-2 in water has not been confirmed, there are studies that have reported on the presence of infectious coronaviruses in water and wastewater samples. Since standard water treatments are not designed to eliminate viruses, it is of utmost importance to explore advanced treatment processes that can improve water treatment and help inactivate viruses when needed. This is the first study to investigate the effects of hydrodynamic cavitation on the inactivation of bacteriophage phi6, an enveloped virus used as a SARS-CoV-2 surrogate in many studies. In two series of experiments with increasing and constant sample temperature, virus reduction of up to 6.3 logs was achieved. Inactivation of phi6 at temperatures of 10 and 20 °C occurs predominantly by the mechanical effect of cavitation and results in a reduction of up to 4.5 logs. At 30 °C, the reduction increases to up to 6 logs, where the temperature-induced increased susceptibility of the viral lipid envelope makes the virus more prone to inactivation. Furthermore, the control experiments without cavitation showed that the increased temperature alone is not sufficient to cause inactivation, but that additional mechanical stress is still required. The RNA degradation results confirmed that virus inactivation was due to the disrupted lipid bilayer and not to RNA damage. Hydrodynamic cavitation, therefore, has the potential to inactivate current and potentially emerging enveloped pathogenic viruses in water at lower, environmentally relevant temperatures

Keywords

enveloped viruses;phi6;SARS-CoV-2;virus inactivation;hydrodynamic cavitation;water decontamination;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL FS - Faculty of Mechanical Engineering
UDC: 532.528:578
COBISS: 148619523 Link will open in a new window
ISSN: 1350-4177
Views: 190
Downloads: 67
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Other data

Secondary language: Slovenian
Secondary keywords: virusi z ovojnico;phi6;SARS-CoV-2;inaktivacija virusov;hidrodinamična kavitacija;dekontaminacija vode;
Type (COBISS): Article
Pages: str. 1-8
Issue: ǂVol. ǂ95
Chronology: May 2023
DOI: 10.1016/j.ultsonch.2023.106400
ID: 18594399
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