Mojca Zupanc (Avtor), Jure Zevnik (Avtor), Arijana Filipić (Avtor), Ion Gutierrez-Aguirre (Avtor), Meta Ješelnik (Avtor), Tamara Košir (Avtor), Jernej Ortar (Avtor), Matevž Dular (Avtor), Martin Petkovšek (Avtor)

Povzetek

The COVID -19 pandemic reminded us that we need better contingency plans to prevent the spread of infectious agents and the occurrence of epidemics or pandemics. Although the transmissibility of SARS-CoV-2 in water has not been confirmed, there are studies that have reported on the presence of infectious coronaviruses in water and wastewater samples. Since standard water treatments are not designed to eliminate viruses, it is of utmost importance to explore advanced treatment processes that can improve water treatment and help inactivate viruses when needed. This is the first study to investigate the effects of hydrodynamic cavitation on the inactivation of bacteriophage phi6, an enveloped virus used as a SARS-CoV-2 surrogate in many studies. In two series of experiments with increasing and constant sample temperature, virus reduction of up to 6.3 logs was achieved. Inactivation of phi6 at temperatures of 10 and 20 °C occurs predominantly by the mechanical effect of cavitation and results in a reduction of up to 4.5 logs. At 30 °C, the reduction increases to up to 6 logs, where the temperature-induced increased susceptibility of the viral lipid envelope makes the virus more prone to inactivation. Furthermore, the control experiments without cavitation showed that the increased temperature alone is not sufficient to cause inactivation, but that additional mechanical stress is still required. The RNA degradation results confirmed that virus inactivation was due to the disrupted lipid bilayer and not to RNA damage. Hydrodynamic cavitation, therefore, has the potential to inactivate current and potentially emerging enveloped pathogenic viruses in water at lower, environmentally relevant temperatures

Ključne besede

enveloped viruses;phi6;SARS-CoV-2;virus inactivation;hydrodynamic cavitation;water decontamination;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FS - Fakulteta za strojništvo
UDK: 532.528:578
COBISS: 148619523 Povezava se bo odprla v novem oknu
ISSN: 1350-4177
Št. ogledov: 190
Št. prenosov: 67
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: virusi z ovojnico;phi6;SARS-CoV-2;inaktivacija virusov;hidrodinamična kavitacija;dekontaminacija vode;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-8
Zvezek: ǂVol. ǂ95
Čas izdaje: May 2023
DOI: 10.1016/j.ultsonch.2023.106400
ID: 18594399
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