Sinteza funkcionaliziranih magnetnih nanodelcev z mikrovalovno pečico za uporabo v biomedicini

diplomsko delo univerzitetnega študijskega programa I. stopnje

Amanda Žižek (Author), Janja Stergar (Mentor), Irena Ban (Co-mentor)

Abstract

V zadnjem času se magnetni nanodelci (MND) vedno več uporabljajo v raznih biomedicinskih aplikacijah. Nanotehnologija omogoča oblikovanje nanodelcev, ki delujejo kot toplotni viri in se aktivirajo pod vplivom zunanjega magnetnega polja. Ko nanodelci v tkivih absorbirajo magnetno energijo, se lokalno segrejejo, kar omogoča usmerjeno uničevanje rakavih celic. Prav tako jih lahko uporabljamo za čiščenje plastičnih odpadkov, predvsem mikro- in nanoplastike iz raznih vodnih tokov. Diplomsko delo obsega mikrovalovno sintezo MND železovega oksida (maghemita), ki smo ga nato funkcionalizirali s citronsko kislino (CK), da smo povečali stabilnost delcev. Primerjali smo, kako vplivajo čas, temperatura in količina dodane kisline na stabilnost nanodelcev. Pridobljene nanodelce smo nato karakterizirali s pomočjo termogravimetrične metode (TGA), dinamičnega sipanja svetlobe (DLS), infrardeče spektroskopije s Fourierovo transformacijo (FTIR), rentgenske praškovne difrakcije (RTG), določevali smo tudi izoelektrično točko izhodnih in oblečenih nanodelcev. Diplomsko delo vsebuje tudi opis posameznih sinteznih stopenj in karakterizacije ter diskusijo vseh dobljenih rezultatov.

Keywords

magnetni nanodelci;citronska kislina;mikrovalovna sinteza;funkcionalizacija;magnetna hipertermija;diplomske naloge;

Data

Language:	Slovenian
Year of publishing:	2023
Typology:	2.11 - Undergraduate Thesis
Organization:	UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher:	[A. Žižek]
UDC:	620.3:57.089(043.2)
COBISS:	166698243
Views:	44
Downloads:	7
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Synthesis of functionalized magnetic nanoparticles with microwave oven for application in biomedicine
Secondary abstract:	Recently, magnetic nanoparticles (MNP) have been increasingly used in various biomedical applications. Nanotechnology allows the creation of nanoparticles that act as heat sources and are activated by an external magnetic field. When the nanoparticles in tissues absorb magnetic energy, they heat up locally, allowing targeted destruction of cancer cells. They can also be used to clean plastic waste, especially micro- and nanoplastics, from various water streams. The thesis involves the microwave synthesis of iron oxide MNP (maghemite), which was then functionalized with citric acid (CA) to increase the stability of the particles. We compared how time, temperature, and the amount of acid added affect the stability of the nanoparticles. The obtained nanoparticles were then characterized by thermogravimetric analysis (TGA), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), X -ray powder diffraction (XRD), and the isoelectric point of the initial and dressed nanoparticles was determined. The thesis also contains a description of the individual synthesis steps and characterizations and a discussion of all the results obtained.
Secondary keywords:	magnetic nanoparticles;citric acid;microwave synthesis;functionalization;magnetic hyperthermia;
Type (COBISS):	Bachelor thesis/paper
Thesis comment:	Univ. v Mariboru, Fak. za kemijo in kemijsko tehnologijo
Pages:	1 spletni vir (1 datoteka PDF (VIII, 29 f.))
ID:	19807138