Sinteza fecu magnetnih nanodelcev s planetarnim mikromlinom za uporabo v biomedicinskih aplikacijah

diplomsko delo univerzitetnega študijskega programa I. stopnje

Tinkara Kovačič (Avtor), Janja Stergar (Mentor), Irena Ban (Komentor)

Povzetek

V diplomskem delu je predstavljena sinteza bimetalnih FeCu magnetnih nanodelcev (MND). Uporabili smo prah železa in bakra ter ju z metodo mehanskega mletja v visokoenergetskem planetarnem mikromlinu mleli različno dolgo časa. Namen diplomske naloge je bil pridobiti in preučiti sintetizirane delce, ki bodo z ustrezno Curiejevo temperaturo (TC) uporabni za zdravljenje na področju magnetne hipertermije. Pri eksperimentalnem delu smo preučevali vpliv treh parametrov, to so masno razmerje med mlevnimi kroglicami in mletim materialom, čas mletja ter vrsta materiala mlevne opreme. Vsem delcem smo s pomočjo termogravimetrične analize (TGA) določili TC in nekatere dodatno okarakterizirali z rentgensko praškovno difrakcijo (RTG). Pri mletju v mlevni opremi iz cirkonijevega dioksida, pod pogoji inertne atmosfere in s kroglicami premera 10 mm, smo najprej spreminjali masno razmerje. Ob tem smo ugotovili, da ima po 10 urnem mletju najnižjo TC zlitina z razmerjem 15:1. S tem razmerjem smo nadaljevali in daljšali čas mletja vse do 35 h. Po 35 h mletja smo s pomočjo modificirane TGA določili TC, ki je znašala 51 °C, kar je najbližje terapevtskemu območju za uporabo v magnetni hipertermiji (41-46 °C). Mletje smo nadaljevali v posodah iz nerjavečega jekla s kroglicami premera 5 mm, tokrat smo mleli v zračni atmosferi. Izvedli smo 10, 15 ter 25 urno sintezo. Vse dobljene TC bimetalne zlitine so bile višje v primerjavi z mletjem v opremi iz cirkonijevega dioksida. Končni rezultat raziskave prikazane v diplomskem delu izpostavlja, da so čas, material mlevne opreme in velikost mlevnih kroglic faktorji z največjim vplivom na lastnosti sintetiziranih FeCu MND.

Ključne besede

FeCu;bimodalna zlitina;magnetni nanodelci;mehansko mletje;Curiejeva temperatura;magnetna hipertermija;diplomske naloge;

Podatki

Jezik:	Slovenski jezik
Leto izida:	2023
Tipologija:	2.11 - Diplomsko delo
Organizacija:	UM FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Založnik:	[T. Kovačič]
UDK:	620.3:57.08(043.2)
COBISS:	167687683
Št. ogledov:	67
Št. prenosov:	9
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Angleški jezik
Sekundarni naslov:	Synthesis of fecu magnetic nanoparticles with a planetary micro mill in biomedical applications
Sekundarni povzetek:	In this work, the synthesis of bimetallic FeCu magnetic nanoparticles (MNDs) is presented. Iron and copper powders were used, which were milled for different times by a mechanical milling process in a high-energy planetary micro mill. The aim of the work was to obtain and study the synthesized particles that will be useful for magnetic hyperthermia treatment at the appropriate Curie temperature (TC). In the experimental work, the influence of three parameters was studied, namely the mass ratio of the grinding balls to the ground material, the milling time, and the type of material of the grinding equipment. All particles were determined by thermogravimetric analysis (TGA), and some were additionally characterized by X-ray powder diffraction (XRD). The mass ratio was first varied during milling in zirconia grinding equipment under an inert atmosphere and with 10 mm diameter balls. It was found that after 10 hours of milling, the alloy had the lowest TC with a ratio of 15:1. This ratio was maintained, and the milling time was increased to 35 hours. After 35 hours of milling, the TC was determined to be 51 °C using a modified TGA, which is closest to the therapeutic range for use in magnetic hyperthermia (41-46 °C). Milling was continued in stainless steel grinding equipment with 5 mm diameter balls, this time under air atmosphere. Synthesis was carried out for 10, 15 and 25 hours. All TCs obtained for the bimetallic alloy were higher than those obtained when milling in zirconia equipment. The result of the research presented in this paper shows that the time, the material of the grinding equipment and the size of the grinding balls are the factors that have the greatest influence on the properties of the synthesized FeCu-MNDs.
Sekundarne ključne besede:	magnetic nanoparticles;mechanical milling;Curie temperature;magnetic hyperthermia;
Vrsta dela (COBISS):	Diplomsko delo/naloga
Komentar na gradivo:	Univ. v Mariboru, Fak. za kemijo in kemijsko tehnologijo
Strani:	1 spletni vir (1 datoteka PDF (VIII, 32 f.))
ID:	19828825