diplomsko delo
Luka Stanković (Author), Marjan Jereb (Mentor)

Abstract

Friedel–Craftsovo aciliranje je najbolj znana in uporabljena metoda za sintezo aromatskih ketonov, ki hkrati velja za eno industrijsko najpomembnejših reakcij. Zaradi okoljevarstvenega, finančnega in zdravstvenega vidika, so bile razvite trajnostne alternative klasični sintezni poti. Med drugimi tudi preko anhidridov karboksilnih kislin in trifluoroocetne kisline. Slednja omogoča sintezo brez uporabe problematičnega katalizatorja AlCl3, ki zaradi toksičnosti in stehiometričnih množin, ki so potrebne za izvedbo reakcije, predstavlja veliko breme za človeka in naravo. V sklopu diplomskega dela sem se osredotočal na sintezo aromatskih ketonov, ki sem jo izvedel tako na klasičen, kakor tudi na alternativni trajnostni način. Sintezni poti se razlikujeta v selektivnosti, reakcijskem času, reagentih, prav tako pa v produktih in njihovih izkoristkih. S pomočjo interpretacije rezultatov spektroskopskih analiz produktov sem predstavil boljši vidik za primerjavo naštetih parametrov pri obeh načinih.

Keywords

aromatski ketoni;Friedel-Craftsovo aciliranje;aciliranje aromatov;klasičen način;trajnostni način;diplomska dela;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher: [L. Stanković]
UDC: 547.572(043.2)
COBISS: 171630595 Link will open in a new window
Views: 62
Downloads: 6
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Other data

Secondary language: English
Secondary title: Synthesis of ketones from aromatic compounds with classical and sustainable approach
Secondary abstract: Friedel–Crafts acylation is the most well-known and widely used method for obtaining aromatic ketones, and it is considered one of the most important industrial reactions. Due to environmental, financial, and health concerns, sustainable alternatives to conventional synthetic routes have been developed. These alternatives include the use of carboxylic acid anhydrides and trifluoroacetic acid. The latter allows for synthesis without the use of the problematic catalyst AlCl3, which poses a significant burden on both humans and the environment due to its toxicity and stoichiometric amounts required for the reaction. In this thesis, I focused on the synthesis of aromatic ketones using both the conventional and alternative sustainable approaches. The synthetic routes differ in selectivity, reaction time, reagents, as well as in the products and their yields. By interpreting the results of spectroscopic analysis of the products, I provided a better understanding for comparing the mentioned parameters in both methods.
Secondary keywords: Friedel-Crafts acylation;aromatic ketones;classical approach;sustainable approach;Aromatske spojine;Univerzitetna in visokošolska dela;
Type (COBISS): Bachelor thesis/paper
Study programme: 1000371
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Biokemija
Pages: 35 str.
ID: 19912996