Andreja Goršek (Author), Marko Tramšek (Author)

Abstract

The main objective of the present study was to design a continuous two-stage bioreactor system for kefir grains production. Based on the experimental data of time-depended kefir grain mass increase and average pH profile during kefir grains batch propagation, parameters of predictive growth and exponential pH models were initially estimated. Afterwards, the non-linear programming (NLP) optimization problem for estimating the optimal volumes of two unequal in series connected continuously stirred tank bioreactors (CSTB) has been developed. The NLP problem is based on criterion of minimal total holding time (MTHT), kefir grain mass balances in CSTB and parameters of the growth and pH models. The results showed that novel kefir grains production plant with two-stage continuous operation, at capacity, qm,KG,pr=3 kgh-1 and conversion, Xo,2=0.980, would primarily require investment in two CSTB with V1=5.93 m3 and V2=5.62 m3, respectively. Technological and economical authorization for a two-stage continuous bioreactor system was mainly confirmed with a more than five times lower total bioreactor volume compared to one-stage plant.

Keywords

kemijska procesna tehnika;bioprocesi;mlečni izdelki;kefir;kefirna zrna;chemical processing;bioprocesses;milk products;kefir grains production;bioreactor design;modeling;optimization;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UM FKKT - Faculty of Chemistry and Chemical Engineering
UDC: 66.01:637.1
COBISS: 12374550 Link will open in a new window
ISSN: 1369-703X
Views: 2450
Downloads: 107
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Other data

Secondary language: English
Secondary keywords: kemijska procesna tehnika;bioprocesi;mlečni izdelki;kefir;kefirna zrna;
URN: URN:SI:UM:
Pages: str. 153-158
Volume: ǂVol. ǂ42
Issue: ǂiss. ǂ1
Chronology: Nov. 2008
DOI: 10.1016/j.bej.2008.06.009
ID: 8716981