Marko Gosak (Author)

Abstract

Calcium ions are an important second messenger in living cells. Calcium signals in form of waves serve as a means of intercellular communication and thus represent a vibrant subject for experimental and theoretical investigations. Here we study the role of cellular variability on the occurrence of ▫$Ca^{2+}$▫ wave propagation in a net of diffusively coupled cells. Dynamics of individual cells is simulated by a mathematical model for ▫$Ca^{2+}$▫ oscillations. Structural diversity of cells is introduced via variations of the bifurcation parameters, which signify cell sensitivity for external stimulation. Remarkably, for sufficient values of variability ▫$Ca^{2+}$▫ waves emerge, which are mostly ordered for intermediate variability strength. We analyze the spatial profile via the autocorrelation function, which confirms aresonance-like response due to the cellular variability. Thus, the reported phenomenon is a novel observation of diversity-induced spatial coherence resonance in a tissue-like media.

Keywords

volovanje;kalcijeve oscilacije;celični sistemi;celična raznolikost;resonanca;dynamic systems;waves;calcium oscillations;resonance;diversity-induced resonance;cellular variability;coupled cells;intracellular processes;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UM FNM - Faculty of Natural Sciences and Mathematics
UDC: 539.2:577.35
COBISS: 16406280 Link will open in a new window
ISSN: 0301-4622
Views: 1462
Downloads: 21
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Other data

Secondary language: English
Secondary title: Cellular diversity promotes intercellular Ca(2+) wave propagation
Secondary keywords: volovanje;kalcijeve oscilacije;celični sistemi;celična raznolikost;resonanca;
URN: URN:SI:UM:
Pages: str. 53-56
Volume: ǂVol. ǂ139
Issue: ǂiss. ǂ1
Chronology: 2009
DOI: 10.1016/j.bpc.2008.10.001
ID: 8723942