Tilen Kopač (Avtor), Aleš Ručigaj (Avtor), Matjaž Krajnc (Avtor)

Povzetek

Controlled release technology has a great potential in pharmaceutical and medical applications to ensure high efficacy of treatment, reduces the aggressive action of the medicines per patient, decreases the cost of treatment and reduces the side effects of the drug as well. In this research, hydrogels from biopolymers were designed for potential use in the drug release systems. The main objective was the manipulation of alginate and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) - oxidized cellulose nanofibers hydrogels crosslinking density by changing the biopolymer and crosslinker concentrations. Rheological measurements of prepared hydrogels were performed to determine the viscosity as a biomedical applicability factor and for determining shear modulus as a basis for theoretical mesh size calculations. The homogeneity of the hydrogel was confirmed by NMR verifying the validity of the mesh size calculations at the same time. In the last stage, the improved mathematical model was developed taking into account the concentration of crosslinker and the concentration of biopolymer in hydrogel as well. The designed model is the first step for the preparation of hydrogels with specific properties.

Ključne besede

biopolimeri;hidrogeli;nanoceluloza;velikost mreže;matematično modeliranje;TEMPO nanocellulose;mesh size;drug diffusion coefficient;controlled drug release;mathematical modelling;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FKKT - Fakulteta za kemijo in kemijsko tehnologijo
UDK: 678
COBISS: 15760387 Povezava se bo odprla v novem oknu
ISSN: 0141-8130
Št. ogledov: 989
Št. prenosov: 255
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: biopolimeri;hidrogeli;nanoceluloza;velikost mreže;matematično modeliranje;
Vrsta dela (COBISS): Članek v reviji
Konec prepovedi (OpenAIRE): 2021-05-17
Strani: str. 557-569
Zvezek: ǂVol. ǂ159
Čas izdaje: 15 Sep. 2020
DOI: 10.1016/j.ijbiomac.2020.05.088
ID: 11724505