Nrf2-interacting nutrients and COVID-19

time for research to develop adaptation strategies

Jean Bousquet (Avtor), Jean-Paul Cristol (Avtor), Wienczyslawa Czarlewski (Avtor), Josep M. Antò i Boquè (Avtor), Adrian Martineau (Avtor), Tari Haahtela (Avtor), Nadja Triller (Avtor), Jure Urbančič (Avtor), Mihaela Zidarn (Avtor), Nika Lalek (Avtor), Bojan Madjar (Avtor), Tonka Poplas-Susič (Avtor), Irma Rozman Sinur (Avtor), Tanja Soklič (Avtor), Katja Triller Vadnal (Avtor), Maja Jošt (Avtor), Peter Kopač (Avtor), Anja Koren (Avtor), Mitja Košnik (Avtor), Karmen Kramer Vrščaj (Avtor), Samo Kreft (Avtor), Susana C. Fonseca (Avtor), Guido Iaccarino (Avtor), Hubert Blain (Avtor), Alessandro Fiocchi (Avtor), Nisera Bajrović (Avtor), Natalija Edelbaher (Avtor)

Povzetek

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR[gamma]:Peroxisome proliferator-activated receptor, NF[kappa]B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2[alpha]:Elongation initiation factor 2[alpha]). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.

Ključne besede

Nrf2;nutrients;TRPA1;

Podatki

Jezik:	Angleški jezik
Leto izida:	2020
Tipologija:	1.02 - Pregledni znanstveni članek
Založnik:	Springer Nature
UDK:	616.9
COBISS:	47724291
ISSN:	2045-7022
Št. ogledov:	922
Št. prenosov:	343
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarne ključne besede:	Nrf2;hranila;TRPA1;Covid-19;SARS-CoV-2;Food;Insulin resistance;Obesity;Hrana;Odpornost proti inzulinu;Debelost;
Komentar vira:	Nasl. z nasl. zaslona; Soavtorji iz Slovenije: Nissera Bajorvić, Natalija Edelbaher, Maja Jošt, Peter Kopač, Anja Koren Jeverica, Mitja Košnik, Karmer Kramer Vrščaj, Samo Kreft, Nika Lalek, Bojan Madjar, Antonija Poplas Susič, Irma Rozman Sinur, Tanja Soklič Košak, Katja Triller, Nadja Triller, Jure Urbancic, Mihaela Zidarn; Opis vira z dne 19. 1. 2021; Št. članka: 58;
Strani:	str. 1-18
Zvezek:	ǂVol. ǂ10
Čas izdaje:	Dec. 2020
DOI:	10.1186/s13601-020-00362-7
ID:	12441014