Skeletal muscle microvascular dysfunction in obesity-related insulin resistance
pathophysiological mechanisms and therapeutic perspectives
Povzetek
Obesity is a worrisomely escalating public health problem globally and one of the leading causes of morbidity and mortality from noncommunicable disease. The epidemiological link between obesity and a broad spectrum of cardiometabolic disorders has been well documented; however, the underlying pathophysiological mechanisms are only partially understood, and effective treatment options remain scarce. Given its critical role in glucose metabolism, skeletal muscle has increasingly become a focus of attention in understanding the mechanisms of impaired insulin function in obesity and the associated metabolic sequalae. We examined the current evidence on the relationship between microvascular dysfunction and insulin resistance in obesity. A growing body of evidence suggest an intimate and reciprocal relationship between skeletal muscle microvascular and glucometabolic physiology. The obesity phenotype is characterized by structural and functional changes in the skeletal muscle microcirculation which contribute to insulin dysfunction and disturbed glucose homeostasis. Several interconnected etiologic molecular mechanisms have been suggested, including endothelial dysfunction by several factors, extracellular matrix remodelling, and induction of oxidative stress and the immunoinflammatory phenotype. We further correlated currently available pharmacological agents that have deductive therapeutic relevance to the explored pathophysiological mechanisms, highlighting a potential clinical perspective in obesity treatment.
Ključne besede
microvascular dysfunction;insulin resistance;obesity treatment;
Podatki
| Jezik: | Angleški jezik |
|---|---|
| Leto izida: | 2022 |
| Tipologija: | 1.02 - Pregledni znanstveni članek |
| Organizacija: | UL MF - Medicinska fakulteta |
| UDK: | 611 |
| COBISS: |
93446147
|
| ISSN: | 1422-0067 |
| Št. ogledov: | 69 |
| Št. prenosov: | 31 |
| Ocena: | 0 (0 glasov) |
| Metapodatki: |
|
Ostali podatki
| Sekundarni jezik: | Slovenski jezik |
|---|---|
| Sekundarne ključne besede: | mikrovaskularna disfunkcija;odpornost proti insulinu;zdravljenje debelosti; |
| Vrsta dela (COBISS): | Članek v reviji |
| Strani: | str. 1-22 |
| Letnik: | ǂVol. ǂ23 |
| Zvezek: | ǂiss. ǂ2 |
| Čas izdaje: | 2022 |
| DOI: | 10.3390/ijms23020847 |
| ID: | 15504159 |
Priporočena dela:
Skeletal muscle microvascular dysfunction in obesity-related insulin resistance
2022,
pathophysiological mechanisms and therapeutic perspectives
Nrf2-interacting nutrients and COVID-19
2020,
time for research to develop adaptation strategies
Metformin and insulin resistance
2022,
ǂa ǂreview of the underlying mechanisms behind changes in GLUT4-mediated glucose transport
Vpliv omega-3-maščobnih kislin na presnovni sindrom
2016,
[zaključna projektna naloga]
Diabetes tipa 2 kot dejavnik tveganja za nastanek Alzheimerjeve bolezni
2016,
zaključna naloga