ǂa ǂreview of the underlying mechanisms behind changes in GLUT4-mediated glucose transport
Rok Herman (Avtor), Nika Aleksandra Kravos (Avtor), Mojca Jensterle Sever (Avtor), Andrej Janež (Avtor), Vita Dolžan (Avtor)

Povzetek

Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and obesity. There is a well-documented correlation between glucose transporter 4 (GLUT4) expression and the level of IR. Therefore, the observed increase in peripheral glucose utilization after metformin treatment most likely comes from the induction of GLUT4 expression and its increased translocation to the plasma membrane. However, the mechanisms behind this effect and the critical metformin targets are still largely undefined. The present review explores the evidence for the crucial role of changes in the expression and activation of insulin signaling pathway mediators, AMPK, several GLUT4 translocation mediators, and the effect of posttranscriptional modifications based on previously published preclinical and clinical models of metformin’s mode of action in animal and human studies. Our aim is to provide a comprehensive review of the studies in this field in order to shed some light on the complex interactions between metformin action, GLUT4 expression, GLUT4 translocation, and the observed increase in peripheral insulin sensitivity.

Ključne besede

metformin;insulin resistance;glucose transport;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 616.379
COBISS: 94576387 Povezava se bo odprla v novem oknu
ISSN: 1422-0067
Št. ogledov: 71
Št. prenosov: 22
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: metformin;odpornost proti insulinu;transport glukoze;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-17
Letnik: ǂVol. ǂ23
Zvezek: ǂiss. ǂ3
Čas izdaje: 2022
DOI: 10.3390/ ijms23031264
ID: 15504024
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