Ross D. Jansen-van Vuuren (Avtor), Rahul Vohra (Avtor)

Povzetek

Baricitinib, typically applied as a treatment for rheumatoid arthritis, has recently attracted the attention of clinicians and researchers as a potential treatment for COVID-19. Naturally, there has been a need for the preparation of the isotope-labelled analogue of baricitinib to probe the pharmacokinetics of baricitinib in this new role. As such, we have developed a simple synthetic route to deuterated [$^2$H$_5$]baricitinib, facilitating its formation over four steps and in a 29% overall yield based on starting [$^2$H$_5$]ethanethiol (19% if we start with [$^2$H$_5$]bromoethane instead). A critical component of the overall process involves the synthesis of [$^2$H$_5$]ethanesulfonyl chloride, and we describe in detail the two routes that were explored to optimize this step.

Ključne besede

baricitinib;COVID-19;devteracija;označevanje z devterijem;SARS-CoV-2;izotopolog;deuteration;deuterium-labelled;isotopologue;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FKKT - Fakulteta za kemijo in kemijsko tehnologijo
UDK: 547.1.057:615
COBISS: 101564163 Povezava se bo odprla v novem oknu
ISSN: 1099-1344
Št. ogledov: 92
Št. prenosov: 42
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: baricitinib;COVID-19;devteracija;označevanje z devterijem;SARS-CoV-2;izotopolog;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 156-161
Letnik: ǂVol. ǂ65
Zvezek: ǂiss. ǂ6
Čas izdaje: 30 May 2022
DOI: 10.1002/jlcr.3969
ID: 15437282
Priporočena dela:
, ni podatka o podnaslovu
, ni podatka o podnaslovu
, lessons from autopsy
, (diplomsko delo)
, immunolabelling as indisputable proof of SARS-CoV-2 virions in infected tissue