ǂa ǂretrospective chart review study (REFLECT)
Urška Janžič (Avtor), Nina Turnšek (Avtor), Mircea Dediu (Avtor), Ivan Shterev Donev (Avtor), Roxana Lupu (Avtor), Gabriela Teodorescu (Avtor), Tudor Ciuleanu (Avtor), Adam Płużański (Avtor)

Povzetek

The targeted therapy with tyrosine kinase inhibitors (TKIs) against the epidermal growth factor receptor mutation (EGFRm) in advanced non-small cell lung cancer (NSCLC) changed the treatment paradigm. REFLECT study (NCT04031898) explored EGFR/T790M testing and treatment patterns in EGFRm NSCLC patients receiving first- or second-generation (1G/2G) EGFR TKIs as front-line (1L) in eight countries. Pooled data from Central Eastern Europe (CEE) countries from this study (Bulgaria, Poland, Romania, Slovenia) are presented here. This physician-led chart review study was conducted in patients with confirmed-EGFRm NSCLC initiating 1L 1G/2G EGFR TKIs between 2015–2018. The CEE cohort included 389 patients receiving 1L erlotinib (37%), afatinib (34%), and gefitinib (29%). Overall, 320 (82%) patients discontinued 1L, and 298 (77%) progression events were registered. Median progression free survival on 1L TKIs was 14.0 (95% CI: 12.6–15.6) months. Median overall survival from 1L start was 26.6 (95% CI: 24.1–29.0) months. Attrition rate between 1L and next line was 30%. Among patients with 1L progression, 200 (67%) were tested for T790M and 58% were positive. This first CEE analysis of treatments and outcomes in EGFRm NSCLC patients highlights the importance of using the most efficacious therapies currently available in 1L to reduce attrition and improve patient outcomes.

Ključne besede

klinične študije;raziskava REFLECT;receptor epidermalnega rastnega faktorja;rak pljuč;real-world study;REFLECT study;epidermal growth factor receptor;lung cancer;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: OI - Onkološki inštitut Ljubljana
Založnik: MDPI
UDK: 616.2
COBISS: 119484931 Povezava se bo odprla v novem oknu
ISSN: 1198-0052
Št. ogledov: 4
Št. prenosov: 1
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarni naslov: Real-world testing practices, treatment patterns and clinical outcomes in patients from Central Eastern Europe with EGFR-mutated advanced non-small cell lung cancer: a retrospective chart review study (REFLECT)
Sekundarne ključne besede: Pljučni rak;Pljučne novotvorbe;Nedrobnocelični karcinom pljuč;Lung neoplasms;Carcinoma, non-small cell lung;Europe, Eastern;Vzhodna Evropa;
Komentar vira: Soavtorica iz Slovenije: Nina Turnšek
Strani: str. 5833-5845
Letnik: ǂVol. ǂ29
Zvezek: ǂiss. ǂ8
Čas izdaje: Aug. 2022
DOI: 10.3390/curroncol29080460
ID: 16411122