which form emerges?
Praveen Chappa (Avtor), Ramesh Naidu Jenjeti (Avtor), Jakob Kljun (Avtor), Sudhir Mittapalli (Avtor), Arthur Pichler (Avtor), Gautam R. Desiraju (Avtor)

Povzetek

Solid form screening is an essential step in drug discovery and development because different solid forms of a drug substance may significantly affect the stability, dissolution, and/or manufacturing of the corresponding drug products. This paper takes up these issues, aiming to provide practical guidance on how to obtain and identify stable solid forms as well as validating proposed crystallization conditions in a set of representative active pharmaceutical ingredients (APIs). Techniques for solid form identification and characterization are discussed from the viewpoint of obtaining forms that are suitable for pharmaceutical development (e.g., physically/chemically stable, easily produced and manipulated on a large scale). Ten representative APIs are taken up for detailed study of their crystallization conditions. The forms are identified definitively using single-crystal X-ray diffraction methods. It is found that for all the APIs in this study, the proposed crystallization methods consistently yield the stable form, as previously identified in the literature.

Ključne besede

polimorf;aktivne farmacevtske učinkovine;kristalizacija;vodikova vez;polymorph;active pharmaceutical ingredients;crystallization;hydrogen bond;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FKKT - Fakulteta za kemijo in kemijsko tehnologijo
UDK: 548.33:615
COBISS: 246153987 Povezava se bo odprla v novem oknu
ISSN: 1528-7483
Št. ogledov: 84
Št. prenosov: 36
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: polimorf;aktivne farmacevtske učinkovine;kristalizacija;vodikova vez;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 4783-4794
Letnik: ǂVol. ǂ25
Zvezek: ǂiss. ǂ13
Čas izdaje: 2 Jul. 2025
DOI: 10.1021/acs.cgd.5c00252
ID: 27412013