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Št. zadetkov: 7
IP - kontaktni center
Aleš Gobec, Gerhard Angleitner, Mitja Solar
Diplomsko delo
Oznake: IP - kontaktni center;IP;VoIP;klicni centri;CTI;H.323;
IP - kontaktni center : diplomsko delo visokošolskega strokovnega študijskega programa
Leto: 2002 Vir: Fakulteta za elektrotehniko, računalništvo in informatiko (UM FERI)
Discovery of novel small-molecule compounds with selective cytotoxicity for Burkittʼs lymphoma cells using 3D ligand-based virtual screening
Martina Gobec, Izidor Sosič, Boris Brus, Aleš Obreza, Stanislav Gobec, Irena Mlinarič-Raščan
Izvirni znanstveni članek
Oznake: Burkittʼs lymphoma;ligand-based;similarity search;selectivity;
We describe a ligand-based approach towards compounds with more specific targeting for Burkittʼs lymphoma. Using three-dimensional ligand-based similarity searches and a previously described hit compound, we have identified six compounds that are chemically different but with similar spatial conform ...
Leto: 2014 Vir: Biotehniška fakulteta (UL BF)
Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodies
Matic Proj, Mitja Zidar, Blaž Lebar, Nika Strašek, Goran Miličić, Aleš Žula, Stanislav Gobec
Izvirni znanstveni članek
Oznake: viscosity;protein formulations;biopharmaceuticals;viscosity-reducing agents;computational screening;
For the development of concentrated monoclonal antibody formulations for subcutaneous administration, the main challenge is the high viscosity of the solutions. To compensate for this, viscosity reducing agents are commonly used as excipients. Here, we applied two computational chemistry approaches ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
OSMI-4-based PROTACs do not influence O-GlcNAc transferase and O-GlcNAcylation levels in cells
Aleša Bricelj, Lara Smrdel, Christian Steinebach, Izidor Sosič, Marko Anderluh, Martina Gobec
Izvirni znanstveni članek
Oznake: zaviralci O-GlcNAc transferaze;OSMI-4;nanomolarni zaviralec OGT;
The O-GlcNAc transferase (OGT) inhibitors disclosed thus far are burdened with certain shortcomings. We have incorporated OSMI-4, a nanomolar OGT inhibitor, into PROTACs. The prepared chimeras failed to induce effective OGT degradation or influence O-GlcNAcylation levels in MM.1S cells.
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Transforming ureas into carbamates
Svit Ferjančič Benetik, Anže Meden, Damijan Knez, Peter Mastnak-Sokolov, Urban Košak, Selena Horvat, Anja Hafner, Rudolf Andrys, Aleš Obreza, Stanislav Gobec
Izvirni znanstveni članek
Oznake: butyrylcholinesterase;p38α mitogen-activated protein kinase;dual inhibitors;carbamate;pseudo-irreversible inhibition;
Given the limited benefits of anticholinergic drugs and the repeated clinical failures of anti-amyloid therapies, the therapeutic focus in Alzheimer's disease (AD) is gradually shifting toward addressing both disease symptoms and its major underlying cause – neuroinflammation. We have developed nove ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Targeting neuroinflammation and cognitive decline
Svit Ferjančič Benetik, Matic Proj, Damijan Knez, Urban Košak, Anže Meden, Katja Krajšek, Anja Hafner, Selena Horvat, Urban Švajger, Nataša Tešić, Aleš Obreza, Stanislav Gobec
Izvirni znanstveni članek
Oznake: central nervous system;inhibition;inhibitors;peptides and proteins;rodent models;
The currently approved drugs for the treatment of Alzheimer’s disease (AD) fail to address its interconnected pathological processes. Inhibition of butyrylcholinesterase (BChE) and p38α mitogen-activated protein kinase (p38α MAPK) offers an innovative dual approach to mitigate two major drivers of n ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Nanofibers with genotyped Bacillus strains exhibiting antibacterial and immunomodulatory activity
Nina Katarina Grilc, Anže Zidar, Petra Kocbek, Tomaž Rijavec, Teja Colja, Aleš Lapanje, Matjaž Jeras, Martina Gobec, Irena Mlinarič-Raščan, Mirjana Gašperlin, Julijana Kristl, Špela Zupančič
Izvirni znanstveni članek
Oznake: probiotics;biofilm-related disease;periodontal disease;bacteria encapsulation;electrospinning;viability;release;erosion;
Biofilm-associated diseases such as periodontitis are widespread and challenging to treat which calls for new strategies for their effective management. Probiotics represent a promising approach for targeted treatment of dysbiosis in biofilm and modulation of host immune response. In this interdisci ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 7
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