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Št. zadetkov: 2
Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design
Robert Kuchta, Christopher Heim, Alexander Herrmann, Samuel Maiwald, Yuen Lam Dora Ng, Izidor Sosič, Tim Keuler, Jan Krönke, Michael Gütschow, Marcus D. Hartmann, Christian Steinebach
Izvirni znanstveni članek
Oznake: the Petasis borono-Mannich reaction;Strecker synthesis;CRBN ligands;
The Petasis borono-Mannich reaction was employed for an alternative entry towards three-branched cereblon ligands. Such compounds are capabable of making multiple interactions with the protein surface and possess a suitable linker exit vector. The high-affinity ligands were used to assemble prototyp ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Amidochelocardin overcomes resistance mechanisms exerted on tetracyclines and natural chelocardin
Fabienne Hennessen, Marcus Miethke, Nestor Zaburannyi, Maria Loose, Tadeja Lukežič, Steffen Bernecker, Stephan Hüttel, Rolf Jansen, Judith Schmiedel, Moritz Fritzenwanker, Can Imirzalioglu, Jörg Vogel, Alexander J. Westermann, Thomas Hesterkamp, Marc Stadler, Florian Wagenlehner, Hrvoje Petković, Jennifer Herrmann, Rolf Müller
Izvirni znanstveni članek
Oznake: antibiotiki;poliketidi;tertaciklin;kelokardin;amidokelokardin;mehanizem delovanja;protimikrobna aktivnost;
The reassessment of known but neglected natural compounds is a vital strategy for providing novel lead structures urgently needed to overcome antimicrobial resistance. Scaffolds with resistance-breaking properties represent the most promising candidates for a successful translation into future thera ...
Leto: 2020 Vir: Biotehniška fakulteta (UL BF)
Št. zadetkov: 2
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