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Št. zadetkov: 2
ǂA ǂtwo-dimensional hyphenated ion-exchange chromatographic platform for simultaneous assessment of AAV8 capsids and impurity fingerprinting in upstream processes
Timotej Žvanut, Tjaša Kašček, Lara Vogrinčič, Petra Dekleva, Sandra Hasić, Anže Martinčič Celjar, Ivana Petrović Koshmak, Blaž Goričar, Mitja Martelanc, Aleš Štrancar, Andreja Gramc-Livk
Izvirni znanstveni članek
Oznake: complex samples;upstream process monitoring;two-dimensional hyphenated liquid chromatography;Adeno-associated virus;full capsid content;
Reliable monitoring of full (F) versus empty (E) adeno-associated virus (AAV) capsids, along with impurity fingerprinting, is essential for optimising upstream processes (USPs). Conventional analytical workflows for USP monitoring, including PCR-ELISA and one-dimensional (1D) liquid chromatography ( ...
Leto: 2026 Vir: Univerza v Novi Gorici (UNG)
Controlling in vitro mRNA polyadenylation by monitoring poly(A) polymerase consumption of ATP
Janja Skok, Pooja Tiwari, Tina Vodopivec, Sergeja Lebar, Ana Ferjančič, Anže Martinčič Celjar, Polona Megušar, Matija Povh, Nina Mencin, Swapnil Bawage, Shree Ram Singh, Artem V. Badasyan, Rok Sekirnik
Izvirni znanstveni članek
Oznake: mRNA;HPLC;poly(A) polymerase (PAP);polyadenylation, poly(A) tail;in-process analytics;
The poly(A) tail of mRNA plays a vital role in mRNA transcript stability, translational efficiency, and immunogenicity. Co-transcriptionally polyadenylated in vitro transcribed (IVT) mRNAs typically contain poly(A) tails of 50–120 nucleotide tail length due to limitations in production of template p ...
Leto: 2026 Vir: Univerza v Novi Gorici (UNG)
Št. zadetkov: 2
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