Iskalni niz:
išči po
išči po
išči po
išči po
Vrsta gradiva:
Jezik:
Št. zadetkov: 2
Refined high-content imaging-based phenotypic drug screening in zebrafish xenografts
Caterina Sturtzel, Sarah Grissenberger, Polyxeni Bozatzi, Eva Scheuringer, Andrea Wenninger-Weinzier, Živa Zajec, Jaka Dernovšek, Susana Pascoal, Virág Gehl, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: fenotipski pregled;cebrica;tumorske celice;presajanje zdravil;ksenografti celic;
Zebrafish xenotransplantation models are increasingly applied for phenotypic drug screening to identify small compounds for precision oncology. Larval zebrafish xenografts offer the opportunity to perform drug screens at high-throughput in a complex in vivo environment. However, the full potential o ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
First dual inhibitors of human topoisomerase IIα and Hsp90 C-terminal domain inhibit the growth of Ewing sarcoma in vitro and in vivo
Jaka Dernovšek, Dunja Urbančič, Živa Zajec, Caterina Sturtzel, Tjaša Goričan, Simona Golič Grdadolnik, Žiga Skok, Janez Ilaš, Nace Zidar, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: cancer;Ewing sarcoma;Hsp90;inhibitor;topoisomerase IIα;zebrafish;
Heat shock protein 90 (Hsp90) and topoisomerase IIα (TopoIIα) are members of the GHKL protein superfamily, both with clinically validated roles as anticancer drug targets. We report the discovery of the first class of dual inhibitors targeting the ATP-binding site of TopoIIα and the C-terminal domai ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
Ključne besede:
Leto izdaje:
Avtorji:
Repozitorij:
Tipologija:
Jezik: