Št. zadetkov: 36
Pregledni znanstveni članek
Oznake:
hyperthermia;targeted drug delivery;SPIONs;gold nanorods;carbon nanotubes;
Glioblastoma multiforme (GBM) is the most common and most aggressive malignant primary brain tumor in humans. Current GBM treatment includes surgery, radiation therapy, and chemotherapy, sometimes supplemented with novel therapies. Despite recent advances, survival of GBM patients remains poor. Majo ...
Leto:
2014
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
cancer genomics;cBioPortal;data mining;epigenetics;gene expression;in silico;
In biomedical research, large-scale profiling of gene expression has become routine and offers a valuable means to evaluate changes in onset and progression of diseases, in particular cancer. An overwhelming amount of cancer genomics data has become publicly available, and the complexity of these da ...
Leto:
2019
Vir:
Nacionalni inštitut za biologijo (NIB)
Kratki znanstveni prispevek
Oznake:
glioblastoma;matične celice;akutna mielonična levkemija;kostni mozeg;glioblastoma stem cells;niches;acute myeloid leukemia;hematopoietic stem cells;bone marrow;C-X-C receptor type 4;stromal-derived factor-1 ▫$[alpha]$▫;plerixafor;
Glioblastoma is the most aggressive and malignant primary brain tumor in adults and has a poor patient survival of only 20 months after diagnosis. This poor patient survival is at least partly caused by glioblastoma stem cells (GSCs), which are slowly-dividing and therefore therapy-resistant. GSCs a ...
Leto:
2020
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
cancer-related fatigue;cytokines;physical activity;pharmacologic;complementary and alternative medicine;
Fatigue is a symptom commonly experienced by survivors of cancer through all stages of the disease trajectory. Survivors identify fatigue as a significant problem which is not adequately addressed by healthcare providers [1•]. Being fatigued has a greater negative impact on functioning and health-re ...
Leto:
2020
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
angiogenesis;endothelial tip cell;proliferative retinopathy;anti-angiogenesis therapy;retinal neovascularization;vascular sprouts;endothelial stalk cell;molecular mediators of angiogenesis;pericytes;
Endothelial tip cells are leading cells at the tips of vascular sprouts coordinating multiple processes during angiogenesis. In the developing retina, tip cells play a tightly controlled, timely role in angiogenesis. In contrast, excessive numbers of tip cells are a characteristic of the chaotic pat ...
Leto:
2013
Vir:
Nacionalni inštitut za biologijo (NIB)
Pregledni znanstveni članek
Oznake:
biokemija;protein, povezan s plazmalemmo;krvno-možganska ovira;cerebralni edem;diabetični makularni edem;plasmalemma vesicle-associated protein;blood-brain barrier;blood-retinal barrier;cerebral edema;diabetic macular edema;
Breakdown of the blood–brain barrier (BBB) or inner blood–retinal barrier (BRB), induced by pathologically elevated levels of vascular endothelial growth factor (VEGF) or other mediators, can lead to vasogenic edema and significant clinical problems such as neuronal morbidity and mortality, or visio ...
Leto:
2018
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
autism spectrum disorder;liver;oxidative stress;inflammation;ferroptosis;
Autism spectrum disorder (ASD) is a complicated neurodevelopmental disorder, and its
etiology is not well understood. It is known that genetic and nongenetic factors determine alterations
in several organs, such as the liver, in individuals with this disorder. The aims of the present
study were to a ...
Leto:
2024
Vir:
Nacionalni inštitut za biologijo (NIB)
Pregledni znanstveni članek
Oznake:
green tea;glioma;
The review discusses the effects of Epigallocatechin-3-gallate Gallate (EGCG) on glioma as a basis for future research on clinical application of EGCG. Epidemiological studies on the effects of green tea or EGCG on the risk of glioma is inconclusive due to the limited number of studies, the inclusio ...
Leto:
2018
Vir:
Nacionalni inštitut za biologijo (NIB)
Pregledni znanstveni članek
Oznake:
glioblastoma;endotelne celice;tumorsko mikrookrožje;hipoksija;glioma stem cells;niches;blood vessels;extracellular matrix;tumor microenvironment;hypoxia;therapy resistance;vasculature;
Glioblastoma is the most lethal primary brain tumor and poor survival of glioblastoma patients is attributed to the presence of glioma stem cells (GSCs). These therapy-resistant, quiescent and pluripotent cells reside in GSC niches, which are specific microenvironments that protect GSCs against radi ...
Leto:
2018
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
endotelijske celice;EGF;celična biologija;
Endothelial cells (ECs) form a precisely regulated polarized monolayer in capillary walls. Vascular endothelial growth factor-A (VEGF-A) induces endothelial hyperpermeability, and VEGF-A applied to the basolateral side, but not the apical side, has been shown to be a strong barrier disruptor in bloo ...
Leto:
2022
Vir:
Nacionalni inštitut za biologijo (NIB)