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Št. zadetkov: 2
Polyfunctionalized α-phenyl-tert-butyl(benzyl)nitrones
Daniel Diez-Iriepa, Damijan Knez, Stanislav Gobec, Isabel Iriepa, Cristóbal de los Ríos, Isaac Bravo, Francisco López-Muñoz, José Marco-Contelles, Dimitra Hadjipavlou-Litina
Izvirni znanstveni članek
Oznake: antioksidanti;butirilholinesteraza;lovilci prostih radikalov;nevroprotekcija;α-fenil-terc-butil(benzil)nitroni;butyrylcholinesterase;free radical scavengers;neuroprotection;α-phenyl-tert-butyl(benzyl)nitrones;in vitro digestion;extractable and bound phenolics;
Nowadays, most stroke patients are treated exclusively with recombinant tissue plasminogen activator, a drug with serious side effects and limited therapeutic window. For this reason, and because of the known effects of oxidative stress on stroke, a more tolerable and efficient therapy for stroke is ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases
Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Stanislav Gobec, José Marco-Contelles
Izvirni znanstveni članek
Oznake: multifunkcionalni ligandi;kinolilnitroni;encimska kinetika;
We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase –hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases. We identified QN 19, a simple, low molecular weig ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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