Št. zadetkov: 10
Doktorska disertacija
Oznake:
cystatin F;glioblastoma;NK cells;immunosuppression;N-glycosylation;
Imunosupresivno mikrookolje povzroča zmanjšano delovanje citotoksičnih imunskih celic in prispeva k imunskemu pobegu rakavih celic. Naravne celice ubijalke (NK) so uporabne kandidatke za zdravljenje raka, ki se še ne uporabljajo v klinični praksi. Celice NK ciljajo tumorske celice s citotoksičnimi g ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Magistrsko delo
Oznake:
cistatin F;katepsin C;pobeg tumorskih celic;kolokalizacija cistatina F;
Izražanje cistatina F v tumorskih celicah
Leto:
2018
Vir:
Fakulteta za farmacijo (UL FFA)
Pregledni znanstveni članek
Oznake:
cisteinski katepsini;cysteine cathepsins;inflammation;autoimmune diseases;cancer;
Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital role in several processes—such as protein degradation, changes in cell signaling, cell morphology, migration and proliferation, and energy metabolism. In addition to their lysosomal function, they are also secre ...
Leto:
2023
Vir:
Institut Jožef Stefan (IJS)
Izvirni znanstveni članek
Oznake:
rakave matične celice;kanabinoidi;celična smrt;biologija raka;genetska toksikologija;cancer stem cells;cannabinoids;cell death;cancer biology;genetic toxicology;
We report here that synthetic cannabinoid WIN 55,212–2 inhibits tumor cell proliferation and induces cell death of oral and pancreatic tumor cells, and the effect is much more pronounced on stem-like/poorly differentiated OSCSCs and MP2 cells when compared to well-differentiated OSCCs, and PL-12 tum ...
Leto:
2022
Vir:
Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake:
protitumorska funkcija;antitumour function;
Objective. Natural killer (NK) cells are the largest innate lymphocyte subset with potent antitumour and antiviral functions. However, clinical utilisation of human NK cells is hampered due to a lack of reliable methods to augment their antitumour potential. We demonstrated technology in which human ...
Leto:
2025
Vir:
Institut Jožef Stefan (IJS)
Izvirni znanstveni članek
Oznake:
cathepsin V;small-molecule inhibitors;antitumor therapy;cancer;cystatin F;
Cathepsin V is a human lysosomal cysteine peptidase with specific functions during pathological processes and is as such a promising therapeutic target. Peptidase inhibitors represent powerful pharmacological tools for regulating excessive proteolytic activity in various diseases. Cathepsin V is hig ...
Leto:
2022
Vir:
Institut Jožef Stefan (IJS)
Izvirni znanstveni članek
Oznake:
cystatin F;immunosuppression;NK cells;N-Glycosylation;
Cystatin F, a cysteine peptidase inhibitor, is a potent modulator of NK cytotoxicity. By inhibiting granule-mediated cytotoxicity pathway, cystatin F induces formation of non-functional NK cell stage, called split-anergy. We show that N-glycosylation determines the localization and cellular function ...
Leto:
2024
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Mitja Bajželj,
Emanuela Senjor,
Nika Boštic,
Matjaž Hladnik,
Snežna Sodin-Šemrl,
Milica Perišić,
Janko Kos,
Alojz Ihan,
Alojzija Hočevar,
Andreja Nataša Kopitar,
Katja Lakota
Izvirni znanstveni članek
Oznake:
imunoglobulin A;IgAVN;vaskulitis IgA;sekvenciranje RNK;immunoglobulin A;IgA vasculitis;RNA sequencing;
Introduction. IgA vasculitis nephritis (IgAVN) manifests in up to 84% of adult patients with IgA vasculitis (IgAV) and is associated with an elevated risk of progression to chronic kidney failure. The underlying pathogenic mechanism of adult IgAVN in leukocytes remain largely uncharacterised. Althou ...
Leto:
2025
Vir:
Institut Jožef Stefan (IJS)
Emanuela Senjor,
Anamarija Habič,
Urban Švajger,
Ana Mitrović,
Matic Proj,
Andrej Porčnik,
Borut Prestor,
Miha Jerala,
Matic Bošnjak,
Stanislav Gobec,
Barbara Breznik,
Janko Kos,
Milica Perišić
Izvirni znanstveni članek
Oznake:
glioblastom;cistatin F;3D-modeli;glioblastoma;cystatin F;3D models;
Introduction: Glioblastoma (GBM) is a highly invasive brain tumor with limited treatment options and poor prognosis. Natural killer (NK) cells are key effectors of antitumor immunity, capable of eliminating cancer stem-like cells. However, GBM creates an immunosuppressive microenvironment that limit ...
Leto:
2025
Vir:
Institut Jožef Stefan (IJS)
Barbara Breznik,
Meng-Wei Ko,
Christopher Tse,
Po-Chun Chen,
Emanuela Senjor,
Bernarda Majc,
Anamarija Habič,
Nicolas Angelillis,
Metka Novak,
Vera Župunski,
Jernej Mlakar,
David Nathanson,
Anahid Jewett
Izvirni znanstveni članek
Oznake:
glioblastom;naravne celice ubijalke;translacijska onkologija;glioblastoma;natural killer cells;translational oncology;
Glioblastomas remain the most lethal primary brain tumors. Natural killer (NK) cell-based therapy is a promising immunotherapeutic strategy in the treatment of glioblastomas, since these cells can select and lyse therapy-resistant glioblastoma stem-like cells (GSLCs). Immunotherapy with super-charge ...
Leto:
2022
Vir:
Nacionalni inštitut za biologijo (NIB)