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Št. zadetkov: 8
Cystatin F as a mediator of immune suppression in tumor microenvironment
Emanuela Senjor, Janko Kos
Doktorska disertacija
Oznake: cystatin F;glioblastoma;NK cells;immunosuppression;N-glycosylation;
Imunosupresivno mikrookolje povzroča zmanjšano delovanje citotoksičnih imunskih celic in prispeva k imunskemu pobegu rakavih celic. Naravne celice ubijalke (NK) so uporabne kandidatke za zdravljenje raka, ki se še ne uporabljajo v klinični praksi. Celice NK ciljajo tumorske celice s citotoksičnimi g ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Izražanje cistatina F v tumorskih celicah
Emanuela Senjor, Janko Kos, Milica Perišić
Magistrsko delo
Oznake: cistatin F;katepsin C;pobeg tumorskih celic;kolokalizacija cistatina F;
Izražanje cistatina F v tumorskih celicah
Leto: 2018 Vir: Fakulteta za farmacijo (UL FFA)
Cysteine cathepsins as therapeutic targets in immune regulation and immune disorders
Emanuela Senjor, Janko Kos, Milica Perišić
Pregledni znanstveni članek
Oznake: cisteinski katepsini;cysteine cathepsins;inflammation;autoimmune diseases;cancer;
Cysteine cathepsins, as the most abundant proteases found in the lysosomes, play a vital role in several processes—such as protein degradation, changes in cell signaling, cell morphology, migration and proliferation, and energy metabolism. In addition to their lysosomal function, they are also secre ...
Leto: 2023 Vir: Institut Jožef Stefan (IJS)
Synthetic cannabinoid WIN 55,212–2 inhibits growth and induces cell death of oral and pancreatic stem-like/poorly differentiated tumor cells
Meng-Wei Ko, Barbara Breznik, Emanuela Senjor, Anahid Jewett
Izvirni znanstveni članek
Oznake: rakave matične celice;kanabinoidi;celična smrt;biologija raka;genetska toksikologija;cancer stem cells;cannabinoids;cell death;cancer biology;genetic toxicology;
We report here that synthetic cannabinoid WIN 55,212–2 inhibits tumor cell proliferation and induces cell death of oral and pancreatic tumor cells, and the effect is much more pronounced on stem-like/poorly differentiated OSCSCs and MP2 cells when compared to well-differentiated OSCCs, and PL-12 tum ...
Leto: 2022 Vir: Nacionalni inštitut za biologijo (NIB)
Osteoclast-expanded supercharged NK cells perform superior antitumour effector functions
Meng-Wei Ko, Ao Mei, Emanuela Senjor, Milica Perišić, Janko Kos, Anahid Jewett
Izvirni znanstveni članek
Oznake: protitumorska funkcija;antitumour function;
Objective. Natural killer (NK) cells are the largest innate lymphocyte subset with potent antitumour and antiviral functions. However, clinical utilisation of human NK cells is hampered due to a lack of reliable methods to augment their antitumour potential. We demonstrated technology in which human ...
Leto: 2025 Vir: Institut Jožef Stefan (IJS)
New inhibitors of cathepsin V impair tumor cell proliferation and elastin degradation and increase immune cell cytotoxicity
Ana Mitrović, Emanuela Senjor, Marko Jukič, Lara Bolčina, Mateja Prunk, Matic Proj, Milica Perišić, Stanislav Gobec, Janko Kos
Izvirni znanstveni članek
Oznake: cathepsin V;small-molecule inhibitors;antitumor therapy;cancer;cystatin F;
Cathepsin V is a human lysosomal cysteine peptidase with specific functions during pathological processes and is as such a promising therapeutic target. Peptidase inhibitors represent powerful pharmacological tools for regulating excessive proteolytic activity in various diseases. Cathepsin V is hig ...
Leto: 2022 Vir: Institut Jožef Stefan (IJS)
Different glycosylation profiles of cystatin F alter the cytotoxic potential of natural killer cells
Emanuela Senjor, Martina Pirro, Urban Švajger, Mateja Prunk, Jerica Sabotič, Anahid Jewett, Paul J. Hensbergen, Milica Perišić, Janko Kos
Izvirni znanstveni članek
Oznake: cystatin F;immunosuppression;NK cells;N-Glycosylation;
Cystatin F, a cysteine peptidase inhibitor, is a potent modulator of NK cytotoxicity. By inhibiting granule-mediated cytotoxicity pathway, cystatin F induces formation of non-functional NK cell stage, called split-anergy. We show that N-glycosylation determines the localization and cellular function ...
Leto: 2024 Vir: Repozitorij Univerze v Ljubljani (RUL)
Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres
Barbara Breznik, Meng-Wei Ko, Christopher Tse, Po-Chun Chen, Emanuela Senjor, Bernarda Majc, Anamarija Habič, Nicolas Angelillis, Metka Novak, Vera Župunski, Jernej Mlakar, David Nathanson, Anahid Jewett
Izvirni znanstveni članek
Oznake: glioblastom;naravne celice ubijalke;translacijska onkologija;glioblastoma;natural killer cells;translational oncology;
Glioblastomas remain the most lethal primary brain tumors. Natural killer (NK) cell-based therapy is a promising immunotherapeutic strategy in the treatment of glioblastomas, since these cells can select and lyse therapy-resistant glioblastoma stem-like cells (GSLCs). Immunotherapy with super-charge ...
Leto: 2022 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 8
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