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Št. zadetkov: 18
Študije izražanja 17[beta]-hidroksisteroid-dehidrogenaze AKR1C3 pri raku endometrija
Gregor Bajc, Tea Lanišnik-Rižner
Diplomsko delo
Oznake: rak endometrija;17[beta]-hidroksisteroid-dehidrogenaza;AKR1C3;estradiol;
Študije izražanja 17[beta]-hidroksisteroid-dehidrogenaze AKR1C3 pri raku endometrija
Leto: 2007 Vir: Medicinska fakulteta (UL MF)
Surface plasmon resonance approach to study drug interactions with SARS-CoV-2 RNA-dependent RNA polymerase highlights treatment potential of suramin
Martina Mravinec, Gregor Bajc, Matej Butala
Izvirni znanstveni članek
Oznake: površinska plazmonska resonanca;suramin;SARS-CoV-2;Covid-19;
The SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) is essential for virus replication, therefore it is a promising drug target. Here we present a surface plasmon resonance approach to study the interaction of RdRp with drugs in real time. We monitored the effect of favipiravir, ribavirin, sofosbuvir ...
Leto: 2021 Vir: Biotehniška fakulteta (UL BF)
CDR1 composition can affect nanobody recombinant expression yields
Marco Orlando, Sara Fortuna, Sandra Oloketuyi, Gregor Bajc, Adi Goldenzweig, Ario De Marco
Izvirni znanstveni članek
Oznake: nanobodies;in silico engineering;mutagenesis;
CDR1 composition can affect nanobody recombinant expression yields
Leto: 2021 Vir: Biotehniška fakulteta (UL BF)
Discovery of a fragment hit compound targeting D-Ala
Matic Proj, Martina Hrast, Gregor Bajc, Rok Frlan, Anže Meden, Matej Butala, Stanislav Gobec
Izvirni znanstveni članek
Oznake: fragment-based drug discovery;hit triage;inhibitors;antibacterial agents;
Bacterial resistance is an increasing threat to healthcare systems, highlighting the need for discovering new antibacterial agents. An established technique, fragment-based drug discovery, was used to target a bacterial enzyme Ddl involved in the biosynthesis of peptidoglycan. We assembled general a ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Comparative analysis of fusion tags used to functionalize recombinant antibodies
Gianluca Veggiani, Barbara Giabbai, Marta S. Semrau, Barbara Medagli, Vincenzo Riccio, Gregor Bajc, Paola Storici, Ario De Marco
Izvirni znanstveni članek
Oznake: antibody functionalization;recombinant antibodies;nanobodies;fusion tags;sortase;
Comparative analysis of fusion tags used to functionalize recombinant antibodies
Leto: 2020 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Effect of humanizing mutations on the stability of the llama single-domain variable region
Miguel A. Soler, Barbara Medagli, Jiewen Wang, Sandra Oloketuyi, Gregor Bajc, He Huang, Sara Fortuna, Ario De Marco
Izvirni znanstveni članek
Oznake: nanobody framework;modeling;nanobody humanization;CDR grafting;
Effect of humanizing mutations on the stability of the llama single-domain variable region
Leto: 2021 Vir: Biotehniška fakulteta (UL BF)
ǂA ǂconsensus protocol for the in silico optimisation of antibody fragments
M. A. Soler, Barbara Medagli, Marta S. Semrau, Paola Storici, Gregor Bajc, Ario De Marco, Alessandro Laio, Sara Fortuna
Izvirni znanstveni članek
Oznake: nanobodies;in silico design;HER2;
A consensus protocol for the in silico optimisation of antibody fragments
Leto: 2019 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
ǂAn ǂanti-HER2 nanobody binds to its antigen HER2 via two independent paratopes
Daniele Ubbiali, Marco Orlando, Matic Kovačič, Claudio Iacobucci, Marta S. Semrau, Gregor Bajc, Sara Fortuna, Gregor Ilc, Barbara Medagli, Sandra Oloketuyi, Ario De Marco
Izvirni znanstveni članek
Oznake: NMR;cross-linking;mass spectrometry;nanobodies;modelling;rational mutagenesis;
An anti-HER2 nanobody binds to its antigen HER2 via two independent paratopes
Leto: 2021 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Inhibition of the SARS-CoV-2 3CLpro main protease by plant polyphenols
Miha Bahun, Marko Jukič, Domen Oblak, Luka Kranjc, Gregor Bajc, Matej Butala, Krištof Bozovičar, Tomaž Bratkovič, Črtomir Podlipnik, Nataša Poklar Ulrih
Izvirni znanstveni članek
Oznake: užitne rastline;fenolne spojine;inhibitorji proteaz;SARS-CoV-2 (virus);polyphenols;COVID-19;SARS-CoV-2;protease inhibitor;
The abundance of polyphenols in edible plants makes them an important component of human nutrition. Considering the ongoing COVID-19 pandemic, a number of studies have investigated polyphenols as bioactive constituents. We applied in-silico molecular docking as well as molecular dynamics supported b ...
Leto: 2022 Vir: Biotehniška fakulteta (UL BF)
Targeting N-acetylglucosaminidase in Staphylococcus aureus with iminosugar inhibitors
Janja Sluga, Tihomir Tomašić, Marko Anderluh, Martina Hrast, Gregor Bajc, Alen Sevšek, Nathaniel I. Martin, Roland J. Pieters, Marjana Novič, Katja Venko
Izvirni znanstveni članek
Oznake: autolysin E;glycoside hydrolase;iminosugars;surface plasmon resonance;enzyme inhibition;
Bacteria are capable of remarkable adaptations to their environment, including undesirable bacterial resistance to antibacterial agents. One of the most serious cases is an infection caused by multidrug-resistant Staphylococcus aureus, which has unfortunately also spread outside hospitals. Therefore ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 18
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