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Št. zadetkov: 2
Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitors
Sjors van Klaveren, Jaka Dernovšek, Žiga Jakopin, Marko Anderluh, Hakon Leffler, Ulf Nilsson, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: β-galaktozid;galektini;raziskava zdravil;diklorotiofenilni analog 59;
Galectins are galactoside-binding proteins that play a role in various pathophysiological conditions, making them attractive targets in drug discovery. We have designed and synthesised a focused library of aromatic 3-triazolyl-1-thiogalactosides targeting their core site for binding of galactose and ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Structure-guided design of D-galactal derivatives with high affinity and selectivity for the galectin-8 n-terminal domain
Mujtaba Hassan, Floriane Baussière, Samo Guzelj, Anders Sundin, Maria Håkansson, Rebeka Kovačič, Hakon Leffler, Tihomir Tomašić, Marko Anderluh, Žiga Jakopin
Izvirni znanstveni članek
Oznake: Galectin-8N;d-galactal;benzimidazole;selectivity;X-ray crystallography;cytokine secretion;
Galectin-8 is a carbohydrate-binding protein that plays a crucial role in tumor progression and metastasis, antibacterial autophagy, modulation of the immune system, and bone remodeling. The design, synthesis, and protein affinity evaluation of a set of C-3 substituted benzimidazole and quinoline d- ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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