Št. zadetkov: 12
Magistrsko delo
Oznake:
zavrialci ksantinske oksidaze;1,2,4-oksadiazol;zamenjava skeleta;Alopurinol;sinteza spojin;
Načrtovanje in sinteza zaviralcev ksantinske oksidaze s piridil-1,2,4-oksadiazolnim ogrodjem
Leto:
2017
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
NOD1 agonist;constrained meso-DAP mimetics;NOD1 activation;innate immune agonist;bioisosteric replacement;rigidization;
The dipeptide d-Glu-meso-DAP (iE-DAP) is the minimal structural fragment capable of activating the innate immune receptor nucleotide-binding oligomerization domain protein (NOD1). The meso-diaminopimelic acid (meso-DAP) moiety is known to be very stringent in terms of the allowed structural modifica ...
Leto:
2020
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
NOD1 agonist;TLR4 agonist;LPS;synergy;cytolytic activity;PBMC;NK cells;K562;
Nucleotide-binding oligomerization domain 1 (NOD1) receptor and Toll-like receptor 4 (TLR4) belong to the family of pattern recognition receptors. Interactions between these receptors profoundly shape the innate immune responses. We previously demonstrated that co-stimulation of peripheral blood mon ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Doktorska disertacija
Oznake:
conjugates;desmuramylpeptides;immune synergy;immunomodulation;NOD2;pattern recognition receptors;TLR7;vaccine adjuvants;
Vaccination, one of the most effective medical interventions ever introduced, primes the immune system to respond to future infections, dramatically reducing the morbidity and mortality of many infectious diseases. The success of vaccination often depends on the careful selection of adjuvants, immun ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Doktorska disertacija
Oznake:
Vaccination, one of the most effective medical interventions ever introduced, primes the immune system to respond to future infections, dramatically reducing the morbidity and mortality of many infectious diseases. The success of vaccination often depends on the careful selection of adjuvants, immun ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Magistrsko delo
Oznake:
Receptor NOD2;dezmuramilpeptidi;agonisti NOD2;adjuvans;optimizacija;
Imunski sistem predstavlja glavno obrambo človeškega organizma pred patogeni, zato je hitro prepoznavanje tujkov in njihova odstranitev ključna za uspešen odziv. Imunske celice prepoznajo s patogeni povezane molekulske vzorce (PAMP) preko receptorjev za prepoznavo vzorcev (PRR), kamor spada tudi rec ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
NOD2;desmuramylpeptide;immunostimulant;adamantane;PBMC cytotoxicity;K562;
The innate immune receptor nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) represents an important target for the development of structurally defined small molecule immunomodulatory compounds that have great potential to be used either as vaccine adjuvants or as general immunos ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
antagonist;homology modeling;NOD2;Nucleotide-binding oligomerization;pharmacophore modeling;virtual screening;
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an innate immune pattern recognition receptor responsible for the recognition of bacterial peptidoglycan fragments. Given its central role in the formation of innate and adaptive immune responses, NOD2 represents a valuable tar ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
immunostimulatory activity;vaccines;immune responses;pattern recognition receptors;synthesis of NOD2 agonist;Toll-like receptor 7;
The success of vaccination with subunit vaccines often relies on the careful choice of adjuvants. There is great interest in developing new adjuvants that can elicit a cellular immune response. Here, we address this challenge by taking advantage of the synergistic cross-talk between two pattern reco ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
agonisti NOD2;adjuvans za cepivo;adamantan;imunopotenciatorji;desmuramilpeptidi;NOD2 agonist;vaccine adjuvant;adamantane;immunopotentiators;desmuramylpeptides;
NOD2 is an innate immune receptor that constitutes an important target for the development of small molecule immunopotentiators with great potential to be used as vaccine adjuvants. We report here the results of an in vivo study of the adjuvant properties of a desmuramylpeptide NOD2 agonist SG29 and ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)