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Organoruthenium complexes with benzo-fused pyrithiones overcome platinum resistance in ovarian cancer cells
Jerneja Kladnik, James P. C. Coverdale, Jakob Kljun, Hilke Burmeister, Petra Lippman, Francesca G. Ellis, Alan M. Jones, Ingo Ott, Isolda Romero-Canelón, Iztok Turel
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Oznake: rutenij;organorutenijevi kompleksi;piritioni;rak jajčnikov;ruthenium;pyrithione;resistance to chemotherapy;cancer;ovarian;thioredoxin;
Drug resistance to existing anticancer agents is a growing clinical concern, with many first line treatments showing poor efficacy in treatment plans of some cancers. Resistance to platinum agents, such as cisplatin, is particularly prevalent in the treatment of ovarian cancer, one of the most commo ...
Leto: 2021 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
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