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Št. zadetkov: 2
Deciphering the cellular behavior of organoruthenium(II)-pyrithionato complexes in ovarian cancers
Maha Alshammari, Uroš Rapuš, Jakob Kljun, Iztok Turel, Isolda Romero-Canelón
Izvirni znanstveni članek
Oznake: organorutenijevi(II) kompleksi s piritionatom;fluorirani derivati;ligandi z donorjem P;protirakavo delovanje;rak jajčnikov;kemoterapija na osnovi kovin;3D-model raka jajčnikov;sferoid;organoruthenium(II) pyrithionato complexes;fluoro derivatives;P-donor ligands;anticancer activity;ovarian cancer;metalbased chemotherapy;3D model for ovarian cancer;spheroid;
Ovarian cancer remains a significant societal burden. Innovations in treatment are limited, and chemotherapy still relies heavily on platinum drugs. This is especially relevant for patients who develop Pt-resistant recurrences. Organoruthenium-arene complexes have shown considerable promise in overc ...
Leto: 2026 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Organoruthenium complexes with benzo-fused pyrithiones overcome platinum resistance in ovarian cancer cells
Jerneja Kladnik, James P. C. Coverdale, Jakob Kljun, Hilke Burmeister, Petra Lippman, Francesca G. Ellis, Alan M. Jones, Ingo Ott, Isolda Romero-Canelón, Iztok Turel
Izvirni znanstveni članek
Oznake: rutenij;organorutenijevi kompleksi;piritioni;rak jajčnikov;ruthenium;pyrithione;resistance to chemotherapy;cancer;ovarian;thioredoxin;
Drug resistance to existing anticancer agents is a growing clinical concern, with many first line treatments showing poor efficacy in treatment plans of some cancers. Resistance to platinum agents, such as cisplatin, is particularly prevalent in the treatment of ovarian cancer, one of the most commo ...
Leto: 2021 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Št. zadetkov: 2
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