Št. zadetkov: 13
Magistrsko delo
Oznake:
pregnanskiX receptor;sinteza bioloških spojin;nepetostno odvisni kalijev kanal;solomonsterol;sinteza bazedoksifenskega skeleta;
Sinteza potencialnih antagonistov pregnanskega X-receptorja in blokatorjev napetnostno odvisnih kalijevih kanalov z bazedoksifenskim ogrodjem
Leto:
2016
Vir:
Fakulteta za farmacijo (UL FFA)
Doktorska disertacija
Oznake:
rutenij;(organo)rutenijeve(II) koordinacijske spojine;kovinski kompleksi;kompleksi prehodnih kovin;pirition;sinteza ligandov;sinteza kompleksov;protitumorska aktivnost;antinevrodegenerativna aktivnost;fotooksidacija;fotoredukcija;doktorske disertacije;
Preučevanje vloge kovinskih ionov v telesu je izjemnega pomena, saj ti uravnavajo mnoge biološke funkcije. Poleg tega so v klinični rabi mnoge zdravilne učinkovine za terapevtske in diagnostične namene, katerih sestavni del struktur so tudi kovinski ioni. Izjemno zanimanje za raziskave na področju ...
Leto:
2020
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Izvirni znanstveni članek
Oznake:
ruthenium-based chemotherapeutics;drug candidates;pyrithione;kinetics study;human serum;speciation analysis;CLC monolithic chromatography;CIM Protein G;DEAE disks;UV spectrometry;isotope dilution inductively coupled plasma mass spectrometry;
The development of ruthenium-based complexes for cancer treatment requires a variety of pharmacological studies, one of them being a drug’s binding kinetics to serum proteins. In this work, speciation analysis was used to study kinetics of ruthenium-based drug candidates with human serum proteins. T ...
Leto:
2020
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Izvirni znanstveni članek
Oznake:
organoruthenium(II) complex;acetylcholinesterase;butyrylcholinesterase;mouse neuromuscular system;ruthenium;Alzheimer disease;neurodegenerative diseases;
Enzyme butyrylcholinesterase (BChE) shows increased activity in some brain regions after progression of Alzheimer’s disease and is therefore one of the therapeutic targets for symptomatic treatment of this neurodegenerative disorder. The organoruthenium(II) complex [(n6-pcymene) Ru(II)(1-hydroxy-3-m ...
Leto:
2023
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
rutenij;organorutenijevi kompleksi;ligandi;derivati piritiona;Alzheimerjeva bolezen;
The increasing number of Alzheimer’s disease (AD) cases requires the development of new improved drug candidates, possessing the ability of more efficient treatment as well as less unwanted side effects. Cholinesterase enzymes are highly associated with the development of AD and thus represent impor ...
Leto:
2020
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Izvirni znanstveni članek
Oznake:
organoruthenium nitrophenanthroline complex;acetylcholinesterase;butyrylcholinesterase;glutathione S-transferase;mouse neuromuscular system;ruthenium;muscle relaxation;physiology;glutathione transferase;
In addition to antibacterial and antitumor effects, synthetic ruthenium complexes have been reported to inhibit several medicinally important enzymes, including acetylcholinesterase (AChE). They may also interact with muscle-type nicotinic acetylcholine receptors (nAChRs) and thus affect the neuromu ...
Leto:
2020
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
rutenij;organorutenijevi kompleksi;ligandi;kemijske lastnosti;biološka aktivnost;
In this work, the various biological activities of eight organoruthenium(II) complexes were evaluated to reveal correlations with their stability and reactivity in aqueous media. Complexes with general formula [Ru(η$^6$-p-cymene)(X,Y)(Z)] were prepared, where (X,Y) represents either an O,Oligand (β- ...
Leto:
2021
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Izvirni znanstveni članek
Oznake:
cholinesterase;enzyme inhibition;glutathione S-transferase;organoruthenium complex;pyrithione;β-diketone;carbonyl;glutathione transferase;
Cholinesterases (ChEs) show increased activities in patients with Alzheimer’s disease, and remain one of the main therapeutic targets for treatment of this neurodegenerative disorder. A library of organoruthenium(II) complexes was prepared to investigate the influence of their structural elements on ...
Leto:
2021
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
protivirusna zdravila;SARS-COV-2;inhibicija;pirition;cink;antiviral agents;SARS-CoV-2;inhibition;pyrithione;zinc;
Zinc pyrithione (1a), together with its analogues 1b–h and ruthenium pyrithione complex 2a, were synthesised and evaluated for the stability in biologically relevant media and anti-SARS-CoV-2 activity. Zinc pyrithione revealed potent in vitro inhibition of cathepsin L (IC$_{50}$=1.88 ± 0.49 µM) and ...
Leto:
2022
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Izvirni znanstveni članek
Oznake:
rutenij;organorutenijevi kompleksi;piritioni;rak jajčnikov;ruthenium;pyrithione;resistance to chemotherapy;cancer;ovarian;thioredoxin;
Drug resistance to existing anticancer agents is a growing clinical concern, with many first line treatments showing poor efficacy in treatment plans of some cancers. Resistance to platinum agents, such as cisplatin, is particularly prevalent in the treatment of ovarian cancer, one of the most commo ...
Leto:
2021
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)