Št. zadetkov: 12
Doktorska disertacija
Oznake:
Rutenij-kemija;organokovinske spojine;holinesterazni inhibitorji;nikotinski receptorji;membranski potenciali;mišična kontrakcija;živčno mišični stik;motorična ploščica;elektrofiziologija;metoda vpete napetosti;
Iz knjižnice novosintetiziranih organorutenijevih(II) arenskih kompleksov smo z biokemično karakterizacijo določili komplekse, ki: i) selektivno zavirajo butirilholinesterazo (BChE); ii) zavirajo holinesteraze; iii) zavirajo holinesteraze in glutation S-transferaze (GST) in iv) selektivno zavirajo G ...
Leto:
2022
Vir:
Veterinarska fakulteta (UL VF)
Pregledni znanstveni članek
Oznake:
Alzheimerjeva bolezen;patofiziologija;etiologija;terapija z zdravili;
Alzheimerjeva bolezen je kronična progresivna nevrodegenerativna bolezen, za katero oboleva vse večje število ljudi po
vsem svetu. Je najpogostejši vzrok za demenco (pri 50–80 % vseh primerov) in obenem tudi najhujša oblika demence, za
katero so značilne kognitivne in vedenjske motnje pri ljudeh, ...
Leto:
2022
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
organoruthenium(II) complex;acetylcholinesterase;butyrylcholinesterase;mouse neuromuscular system;ruthenium;Alzheimer disease;neurodegenerative diseases;
Enzyme butyrylcholinesterase (BChE) shows increased activity in some brain regions after progression of Alzheimer’s disease and is therefore one of the therapeutic targets for symptomatic treatment of this neurodegenerative disorder. The organoruthenium(II) complex [(n6-pcymene) Ru(II)(1-hydroxy-3-m ...
Leto:
2023
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
organoruthenium nitrophenanthroline complex;acetylcholinesterase;butyrylcholinesterase;glutathione S-transferase;mouse neuromuscular system;ruthenium;muscle relaxation;physiology;glutathione transferase;
In addition to antibacterial and antitumor effects, synthetic ruthenium complexes have been reported to inhibit several medicinally important enzymes, including acetylcholinesterase (AChE). They may also interact with muscle-type nicotinic acetylcholine receptors (nAChRs) and thus affect the neuromu ...
Leto:
2020
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
Nervous System Diseases;Cholinesterase Inhibitors;
The management of neurological disorders such as dementia associated with Alzheimer’s or Parkinson’s
disease includes the use of cholinesterase inhibitors. These compounds can slow down the progression
of these diseases and can also be used in the treatment of glaucoma and myasthenia gravis. The m ...
Leto:
2022
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
homology screening;in silico screening;in vitro enzymatic studies;cholinesterase;AChE inhibitor;antifouling;
The search for effective yet environmentally friendly strategies to prevent marine
biofouling is hampered by the large taxonomic diversity amongst fouling organisms and
a lack of well-defined conserved molecular targets. The acetylcholinesterase enzyme
catalyses the breakdown of the neurotransmit ...
Leto:
2021
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
cholinesterase;enzyme inhibition;glutathione S-transferase;organoruthenium complex;pyrithione;β-diketone;carbonyl;glutathione transferase;
Cholinesterases (ChEs) show increased activities in patients with Alzheimer’s disease, and remain one of the main therapeutic targets for treatment of this neurodegenerative disorder. A library of organoruthenium(II) complexes was prepared to investigate the influence of their structural elements on ...
Leto:
2021
Vir:
Veterinarska fakulteta (UL VF)
Izvirni znanstveni članek
Oznake:
stranski učinki;egerolizini;Apis mellifera;bioinsekticidi;erilizin A;protein z domeno MACPF;netarčni organizmi;bukov ostrigar;Porcellio scaber;toksičnost;adverse effects;aegerolysins;bioinsecticides;erylysin A;MACPF protein;non-target organisms;oyster mushroom;toxicity;
Aegerolysin proteins ostreolysin A6 (OlyA6), pleurotolysin A2 (PlyA2) and erylysin A (EryA) produced by the mushroom genus Pleurotus bind strongly to an invertebrate-specific membrane sphingolipid, and together with a protein partner pleurotolysin B (PlyB), form transmembrane pore complexes. This po ...
Leto:
2021
Vir:
Biotehniška fakulteta (UL BF)
Ulf Göransson,
Lindon W. K. Moodie,
Luke P. Robertson,
Neda Safa,
Tomaž Trobec,
Darren C. Holland,
Blazej Slazak,
Erik Jacobsson,
Jeffrey A. Hawkes,
Robert Frangež,
Kristina Sepčić
Izvirni znanstveni članek
Oznake:
Cholinesterase Inhibitors;Papaver;Alkaloids;
During a research program to identify new cholinesterase inhibitors of natural origin, two new 7,8-didehydroprotoberberine alkaloids (1 and 2) and nine known compounds (3−11) were isolated from the capsules of the common ornamental poppy, Papaver setiferum (previously P. pseudo-orientale). Despite t ...
Leto:
2022
Vir:
Veterinarska fakulteta (UL VF)
Doktorska disertacija
Oznake:
omrežne naprave;večjedrne platforme;razporejanje omrežnega prometa;vzporedni sistemi;virtualizacija omrežij;učinkovitost;uravnovešenje bremena;zamenjava vrstnega reda omrežnih paketov;disertacije;
V doktorski disertaciji obravnavamo izboljšave večjedrnih omrežnih naprav na področju zmogljivosti in učinkovitosti. Glavni motiv za izboljšave so stalno prisotne zahteve po hitrih in zanesljivih povezavah med elektronskimi napravami vseh tipov. Te naprave omogočajo uporabnikom številne omrežne stor ...
Leto:
2015
Vir:
Fakulteta za elektrotehniko (UL FE)