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Št. zadetkov: 2
Development of potent cholinesterase inhibitors based on a marine pharmacophore
Vijayaragavan Elumalai, Tomaž Trobec, Maja Grundner, Christophe Labriere, Robert Frangež, Kristina Sepčić, Jørn H. Hansen, Johan Svenson
Izvirni znanstveni članek
Oznake: Nervous System Diseases;Cholinesterase Inhibitors;
The management of neurological disorders such as dementia associated with Alzheimer’s or Parkinson’s disease includes the use of cholinesterase inhibitors. These compounds can slow down the progression of these diseases and can also be used in the treatment of glaucoma and myasthenia gravis. The m ...
Leto: 2022 Vir: Veterinarska fakulteta (UL VF)
Using virtual AChE homology screening to identify small molecules with the ability to inhibit marine biofouling
Homayon John Arabshahi, Tomaž Trobec, Valentin Foulon, Claire Hellio, Robert Frangež, Kristina Sepčić, Patrick Cahill, Johan Svenson
Izvirni znanstveni članek
Oznake: homology screening;in silico screening;in vitro enzymatic studies;cholinesterase;AChE inhibitor;antifouling;
The search for effective yet environmentally friendly strategies to prevent marine biofouling is hampered by the large taxonomic diversity amongst fouling organisms and a lack of well-defined conserved molecular targets. The acetylcholinesterase enzyme catalyses the breakdown of the neurotransmit ...
Leto: 2021 Vir: Veterinarska fakulteta (UL VF)
Št. zadetkov: 2
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