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Št. zadetkov: 6
Računska ocena vpliva znotrajceličnih presnovnih in signalnih poti ter medcelične komunikacije na izločanje glukagona in inzulina
Jan Zmazek, Marko Marhl
Doktorska disertacija
Oznake: disertacije;celica beta;celica alfa;modeliranje;presnova;cAMP;aminokisline;kalcij;medcelične mreže;
Doktorska disertacija proučuje fiziološke lastnosti celic alfa in beta z uporabo matematičnega modeliranja, omrežnih znanosti in drugih sodobnih biofizikalnih pristopov. V prvem delu disertacije predstavimo matematični model presnove in hormonskega izločanja obeh tipov celic. Rezultati modela kažejo ...
Leto: 2022 Vir: Fakulteta za naravoslovje in matematiko (UM FNM)
Modeling the amino acid effect on glucagon secretion from pancreatic alpha cells
Jan Zmazek, Vladimir Grubelnik, Rene Markovič, Marko Marhl
Izvirni znanstveni članek
Oznake: sladkorna bolezen;izločanje hormonov;glukoza;aminokisline;ne zaključna dela;diabetes;hormone secretion;glucose;amino acid;cAMP;
Type 2 Diabetes Mellitus (T2DM) is a burdensome problem in modern society, and intensive research is focused on better understanding the underlying cellular mechanisms of hormone secretion for blood glucose regulation. T2DM is a bi-hormonal disease, and in addition to 100 years of increasing knowled ...
Leto: 2022 Vir: Fakulteta za naravoslovje in matematiko (UM FNM)
Role of cAMP in double switch of glucagon secretion
Jan Zmazek, Vladimir Grubelnik, Rene Markovič, Marko Marhl
Izvirni znanstveni članek
Oznake: pancreatic alpha cell;glucagon;cAMP;mathematical model;diabetes;cellular bioenergetics;
Glucose metabolism plays a crucial role in modulating glucagon secretion in pancreatic alpha cells. However, the downstream effects of glucose metabolism and the activated signaling pathways influencing glucagon granule exocytosis are still obscure. We developed a computational alpha cell model, imp ...
Leto: 2021 Vir: Fakulteta za naravoslovje in matematiko (UM FNM)
ǂThe ǂrole of anaplerotic metabolism of glucose and glutamine in insulin secretion
Vladimir Grubelnik, Jan Zmazek, Marko Gosak, Marko Marhl
Izvirni znanstveni članek
Oznake: matematični modeli;beta celica trebušne slinavke;piruvat-malatni cikel;mathematical models;pancreatic beta cell;pyruvate-malate cycle;
We propose a detailed computational beta cell model that emphasizes the role of anaplerotic metabolism under glucose and glucose-glutamine stimulation. This model goes beyond the traditional focus on mitochondrial oxidative phosphorylation and ATP-sensitive K+ channels, highlighting the predominant ...
Leto: 2024 Vir: Fakulteta za elektrotehniko, računalništvo in informatiko (UM FERI)
Mitochondrial dysfunction in pancreatic alpha and beta cells associated with type 2 diabetes mellitus
Vladimir Grubelnik, Jan Zmazek, Rene Markovič, Marko Gosak, Marko Marhl
Izvirni znanstveni članek
Oznake: endokrine celice trebušne slinavke;matematični modeli;mitohondrijska disfunkcija;celularna bioenergetika;diabetes;glukagon;inzulin;ne zaključna dela;pancreatic endocrine cells;mathematical model;mitochondrial dysfunction;cellular bioenergetics;glucagon;insulin;
Type 2 diabetes mellitus is a complex multifactorial disease of epidemic proportions. It involves genetic and lifestyle factors that lead to dysregulations in hormone secretion and metabolic homeostasis. Accumulating evidence indicates that altered mitochondrial structure, function, and particularly ...
Leto: 2020 Vir: Fakulteta za elektrotehniko, računalništvo in informatiko (UM FERI)
Assessing different temporal scales of calcium dynamics in networks of beta cell populations
Jan Zmazek, Maša Skelin, Rene Markovič, Jurij Dolenšek, Marko Marhl, Andraž Stožer, Marko Gosak
Izvirni znanstveni članek
Oznake: islets of Langerhans;beta cell network;calcium oscillations;multimodal activity analysis;confocal imaging;functional connectivity;multiplex network;
Beta cells within the pancreatic islets of Langerhans respond to stimulation with coherent oscillations of membrane potential and intracellular calcium concentration that presumably drive the pulsatile exocytosis of insulin. Their rhythmic activity is multimodal, resulting from networked feedback in ...
Leto: 2021 Vir: Fakulteta za naravoslovje in matematiko (UM FNM)
Št. zadetkov: 6
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