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Št. zadetkov: 2
Identification of a conserved chemokine receptor motif that enables ligand discrimination
Olav Larsen, Wijnand J. C. van der Velden, Maša Mavri, Sara Schuermans, Pia C. Rummel, Stefanie Karlshøj, Martin Gustavsson, Paul Proost, Jon Våbenø, Mette Marie Rosenklide
Izvirni znanstveni članek
Oznake: GTP-binding proteins;monocyte chemoattractant proteins;macrophage inflammatory proteins;receptors;chemokine;
Extensive ligand-receptor promiscuity in the chemokine signaling system balances beneficial redundancy and specificity. However, this feature poses a major challenge to selectively modulate the system pharmacologically. Here, we identified a conserved cluster of three aromatic receptor residues that ...
Leto: 2022 Vir: Veterinarska fakulteta (UL VF)
Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization
Astrid S. Jørgensen, Viktorija Daugvilaite, Katia De Filippo, Christian Berg, Maša Mavri, Tau Benned-Jensen, Goda Juzenaite, Gertrud Malene Hjortø, Sara Rankin, Jon Våbenø, Mette Marie Rosenklide
Izvirni znanstveni članek
Oznake: stem cells;hematopoietic stem cells;GTP-binding proteins;molecular medicine;receptor pharmacology;
Following the FDA-approval of the hematopoietic stem cell (HSC) mobilizer plerixafor, orally available and potent CXCR4 antagonists were pursued. One such proposition was AMD11070, which was orally active and had superior antagonism in vitro; however, it did not appear as effective for HSC mobilizat ...
Leto: 2021 Vir: Veterinarska fakulteta (UL VF)
Št. zadetkov: 2
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