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Št. zadetkov: 6
Methods for studying endocytotic pathways of herpesvirus encoded G protein-coupled receptors
Maša Mavri, Katja Spiess, Mette Marie Rosenklide, Catrin Rutland, Milka Vrecl, Valentina Kubale
Pregledni znanstveni članek
Oznake: endocytosis;G-protein coupled receptors;herpesvirus;methods;Herpesviridae;
Endocytosis is a fundamental process involved in trafficking of various extracellular and transmembrane molecules from the cell surface to its interior. This enables cells to communicate and respond to external environments, maintain cellular homeostasis, and transduce signals. G protein-coupled rec ...
Leto: 2020 Vir: Veterinarska fakulteta (UL VF)
Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Maša Mavri, Sanja Glisic, Milan Sencanski, Milka Vrecl, Mette Marie Rosenklide, Katja Spiess, Valentina Kubale
Izvirni znanstveni članek
Oznake: Herpesvirus 4;human;Dynamins;Caveolins;beta-Arrestins;
Background: The viral G protein-coupled receptor (vGPCR) BILF1 encoded by the Epstein-Barr virus (EBV) is an oncogene and immunoevasin and can downregulate MHC-I molecules at the surface of infected cells. MHC-I downregulation, which presumably occurs through co-internalization with EBV-BILF1, is pr ...
Leto: 2023 Vir: Veterinarska fakulteta (UL VF)
Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1
Naotaka Tsutsumi, Qianhui Qu, Maša Mavri, Maibritt S. Baggesen, Shoji Maeda, Deepa Waghray, Christian Berg, Brian K. Kobilka, Mette Marie Rosenklide, Georgios Skiniotis, K. Christopher Garcia
Izvirni znanstveni članek
Oznake: Epstein-Barr virus;G protein;G protein-coupled receptor;GPCR;cryo-EM;immune evasion;ligand-indpendent signaling;receptor;signaling;viral GPCR;
Epstein-Barr virus (EBV) encodes a G protein-coupled receptor (GPCR) termed BILF1 that is essential for EBV-mediated immunosuppression and oncogenesis. BILF1 couples with inhibitory G protein (Gi), the major intracellular signaling effector for human chemokine receptors, and exhibits constitutive si ...
Leto: 2021 Vir: Veterinarska fakulteta (UL VF)
Identification of a conserved chemokine receptor motif that enables ligand discrimination
Olav Larsen, Wijnand J. C. van der Velden, Maša Mavri, Sara Schuermans, Pia C. Rummel, Stefanie Karlshøj, Martin Gustavsson, Paul Proost, Jon Våbenø, Mette Marie Rosenklide
Izvirni znanstveni članek
Oznake: GTP-binding proteins;monocyte chemoattractant proteins;macrophage inflammatory proteins;receptors;chemokine;
Extensive ligand-receptor promiscuity in the chemokine signaling system balances beneficial redundancy and specificity. However, this feature poses a major challenge to selectively modulate the system pharmacologically. Here, we identified a conserved cluster of three aromatic receptor residues that ...
Leto: 2022 Vir: Veterinarska fakulteta (UL VF)
Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization
Astrid S. Jørgensen, Viktorija Daugvilaite, Katia De Filippo, Christian Berg, Maša Mavri, Tau Benned-Jensen, Goda Juzenaite, Gertrud Malene Hjortø, Sara Rankin, Jon Våbenø, Mette Marie Rosenklide
Izvirni znanstveni članek
Oznake: stem cells;hematopoietic stem cells;GTP-binding proteins;molecular medicine;receptor pharmacology;
Following the FDA-approval of the hematopoietic stem cell (HSC) mobilizer plerixafor, orally available and potent CXCR4 antagonists were pursued. One such proposition was AMD11070, which was orally active and had superior antagonism in vitro; however, it did not appear as effective for HSC mobilizat ...
Leto: 2021 Vir: Veterinarska fakulteta (UL VF)
Epstein-Barr virus-encoded BILF1 orthologues from porcine lymphotropic herpesviruses display common molecular functionality
Maša Mavri, Valentina Kubale, Daniel P. Depledge, Jianmin Zuo, Christene A. Huang, Judith Breuer, Milka Vrecl, Michael A. Jarvis, Eva Jarc, Toni Petan, Bernhard Ehlers, Mette Marie Rosenklide, Katja Spiess
Izvirni znanstveni članek
Oznake: Epstein-Barr virus;porcine lymphotropic herpesviruses (PLHV);BILF1;G protein signaling;MHC class I;drug target;post-transplant lymphoproliferative disease;in-vivo model;
Infection of immunosuppressed transplant patients with the human γ-herpesvirus Epstein-Barr virus (EBV) is associated with post-transplant lymphoproliferative disease (PTLD), an often fatal complication. Immunosuppressed miniature pigs infected with γ-herpesvirus porcine lymphotropic herpesvirus 1 ( ...
Leto: 2022 Vir: Veterinarska fakulteta (UL VF)
Št. zadetkov: 6
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