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Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1
Naotaka Tsutsumi, Qianhui Qu, Maša Mavri, Maibritt S. Baggesen, Shoji Maeda, Deepa Waghray, Christian Berg, Brian K. Kobilka, Mette Marie Rosenklide, Georgios Skiniotis, K. Christopher Garcia
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Oznake: Epstein-Barr virus;G protein;G protein-coupled receptor;GPCR;cryo-EM;immune evasion;ligand-indpendent signaling;receptor;signaling;viral GPCR;
Epstein-Barr virus (EBV) encodes a G protein-coupled receptor (GPCR) termed BILF1 that is essential for EBV-mediated immunosuppression and oncogenesis. BILF1 couples with inhibitory G protein (Gi), the major intracellular signaling effector for human chemokine receptors, and exhibits constitutive si ...
Leto: 2021 Vir: Veterinarska fakulteta (UL VF)
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