Iskalni niz:
išči po
išči po
išči po
išči po
Vrsta gradiva:
Jezik:
Št. zadetkov: 4
N-hydroxy-N-propargylamide derivatives of ferulic acid
Oscar M. Bautista-Aguilera, José M. Alonso, Marco Catto, Isabel Iriepa, Damijan Knez, Stanislav Gobec, José Marco-Contelles
Izvirni znanstveni članek
Oznake: cholinesterases;ferulic acid;molecular modelling;monoamine oxidase;radical-scavenger;antioxidant;
Alzheimer’s disease (AD) is a complex disorder characterized by impaired neurotransmission in cholinergic and monoaminergic neurons, which, in combination with the accumulation of misfolded proteins and increased oxidative stress, leads to the typical features of the disease at the biomolecular leve ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases
Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Stanislav Gobec, José Marco-Contelles
Izvirni znanstveni članek
Oznake: multifunkcionalni ligandi;kinolilnitroni;encimska kinetika;
We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase –hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases. We identified QN 19, a simple, low molecular weig ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Polyfunctionalized α-phenyl-tert-butyl(benzyl)nitrones
Daniel Diez-Iriepa, Damijan Knez, Stanislav Gobec, Isabel Iriepa, Cristóbal de los Ríos, Isaac Bravo, Francisco López-Muñoz, José Marco-Contelles, Dimitra Hadjipavlou-Litina
Izvirni znanstveni članek
Oznake: antioksidanti;butirilholinesteraza;lovilci prostih radikalov;nevroprotekcija;α-fenil-terc-butil(benzil)nitroni;butyrylcholinesterase;free radical scavengers;neuroprotection;α-phenyl-tert-butyl(benzyl)nitrones;in vitro digestion;extractable and bound phenolics;
Nowadays, most stroke patients are treated exclusively with recombinant tissue plasminogen activator, a drug with serious side effects and limited therapeutic window. For this reason, and because of the known effects of oxidative stress on stroke, a more tolerable and efficient therapy for stroke is ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Synthesis and biological evaluation of benzochromenopyrimidinones as cholinesterase inhibitors and potent antioxidant, non-hepatotoxic agents for Alzheimer's disease
Youssef Dgachi, Oscar M. Bautista-Aguilera, Mohamed Benchekroun, Hélène Martin, Alexandre Bonet, Damijan Knez, Justyna Godyń, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Jana Janockova, Ondrej Soukup, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Izvirni znanstveni članek
Oznake: Alzheimer's disease;quinazolinones;multicomponent reactions;multitarget-directed ligands;antioxidants;cholinesterase inhibitors;hepatotoxicity;
We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixed-type inhibition of human acetylcholinesterase (I ...
Leto: 2016 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 4
Ključne besede:
Leto izdaje:
Avtorji:
Repozitorij:
Tipologija:
Jezik: