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Št. zadetkov: 2
Heterobifunctional ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins
Yuen Lam Dora Ng, Aleša Bricelj, Jacqueline A. Jansen, Arunima Murgai, Kirsten Peter, Katherine A. Donovan, Michael Gütschow, Jan Krönke, Christian Steinebach, Izidor Sosič
Izvirni znanstveni članek
Oznake: antagonists;degradation;ligands;mixtures;peptides;proteins;
Proteolysis targeting chimeras (PROTACs) represent a new pharmacological modality to inactivate disease-causing proteins. PROTACs operate via recruiting E3 ubiquitin ligases, which enable the transfer of ubiquitin tags onto their target proteins, leading to proteasomal degradation. However, several ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Equinatoxin II permeabilizing activity depends on the presence of sphingomyelin and lipid phase coexistence
Peter Schön, Ana J. García-Sáez, Petra Malovrh, Kirsten Bacia, Gregor Anderluh, Petra Schwille
Izvirni znanstveni članek
Oznake: equinatoxin;toroidal pore;phase separation;giant unilamellar vesicle;pore forming toxin;lipid raft;
Equinatoxin II permeabilizing activity depends on the presence of sphingomyelin and lipid phase coexistence
Leto: 2008 Vir: Biotehniška fakulteta (UL BF)
Št. zadetkov: 2
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