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Asymmetric T-segment binding and gate dynamics govern the final stages of the type IIA topoisomerase catalytic cycle
Kristina Stevanović, Barbara Herlah, Matic Pavlin, Andrej Perdih
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Oznake: biokemija;topoizomeraza IIα;DNK;molekulska dinamika;type IIA DNA topoisomerase;T-segment;C-gate;catalytic cycle;molecular dynamics;
Type IIA DNA topoisomerases are molecular nanomachines that alter DNA topology during essential cellular processes. The final steps of their catalytic cycle, after translocation of the transported (T-) segment into the C- gate, are still not fully understood. Here, we performed all-atom molecular dy ...
Leto: 2025 Vir: Kemijski inštitut (KI)
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