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Fragment-sized and bidentate (immuno)proteasome inhibitors derived from cysteine and threonine targeting warheads
Levente Kollár, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Tímea Imre, Ágnes Gömöry, László Petri, Stanislav Gobec, Izidor Sosič
Izvirni znanstveni članek
Oznake: immunoproteasome;benzoxazole-2-carbonitriles;bidentate covalent inhibitors;fragments;non-covalent recognition;
Constitutive- and immunoproteasomes are part of the ubiquitin–proteasome system (UPS), which is responsible for the protein homeostasis. Selective inhibition of the immunoproteasome offers opportunities for the treatment of numerous diseases, including inflammation, autoimmune diseases, and hematolo ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
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