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Št. zadetkov: 9
Skeletal muscle uncoupling proteins in mice models of obesity
Lidija Križančić Bombek, Maša Čater
Pregledni znanstveni članek
Oznake: fiziologija človeka;patofiziologija;diabetes;debelost;beljakovine;skeletne mišice;laboratorijske miši;
Obesity and accompanying type 2 diabetes are among major and increasing worldwide problems that occur fundamentally due to excessive energy intake during its expenditure. Endotherms continuously consume a certain amount of energy to maintain core body temperature via thermogenic processes, mainly in ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Protective role of mitochondrial uncoupling proteins against age-related oxidative stress in type 2 diabetes mellitus
Maša Čater, Lidija Križančić Bombek
Pregledni znanstveni članek
Oznake: medicina;diabetes;staranje;oksidativni stres;genetika;poškodbe DNA;mitohondrijski DNA;
The accumulation of oxidative damage to DNA and other biomolecules plays an important role in the etiology of aging and age-related diseases such as type 2 diabetes mellitus (T2D), atherosclerosis, and neurodegenerative disorders. Mitochondrial DNA (mtDNA) is especially sensitive to oxidative stress ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Individualizacija avtogenega treninga za zniževanje anksioznosti s pomočjo metode biofeedback, temelječe na spremljanju variabilnosti srčne frekvence
Urška Drofenik, Andraž Stožer, Saša Zorjan, Lidija Križančić Bombek
Magistrsko delo
Oznake: anksioznost;biofeedback;variabilnost srčne frekvence;magistrska dela;
Biofeedback, temelječ na variabilnosti srčne frekvence (HRV biofeedback), neposredno spodbuja barorefleks, respiratorno sinusno aritmijo, parasimpatično aktivnost in stimulira različne homeostatične reflekse. Pri HRV biofeedbacku učimo ljudi počasnega dihanja pri njihovi resonančni frekvenci, ki se ...
Leto: 2022 Vir: Filozofska fakulteta (UM FF)
Glucose-stimulated calcium dynamics in beta cells from male C57BL/6J, C57BL/6N, and NMRI mice: a comparison of activation, activity, and deactivation properties in tissue slices
Viljem Pohorec, Lidija Križančić Bombek, Maša Skelin, Jurij Dolenšek, Andraž Stožer
Izvirni znanstveni članek
Oznake: beta cell;mouse models;calcium imaging;glucose-dependence;tissue slice;
Although mice are a very instrumental model in islet beta cell research, possible phenotypic differences between strains and substrains are largely neglected in the scientific community. In this study, we show important phenotypic differences in beta cell responses to glucose between C57BL/6J, C57BL ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Uporaba simulacij za poglabljanje predkliničnega znanja medicine
Luka Petravić, Luka Ternar, Maja Toplak, Sebastjan Bevc, Monika Sobočan, Lidija Križančić Bombek
Končno poročilo o rezultatih raziskav
Oznake: simulacija;ohranitev znanja;predklinično izobraževanje;osnovne znanosti;
Uporaba simulacij za poglabljanje predkliničnega znanja medicine
Leto: 2020 Vir: Medicinska fakulteta (UM MF)
Glucose-dependent activation, activity, and deactivation of beta cell networks in acute mouse pancreas tissue slices
Andraž Stožer, Maša Skelin, Marko Gosak, Lidija Križančić Bombek, Viljem Pohorec, Marjan Rupnik, Jurij Dolenšek
Izvirni znanstveni članek
Oznake: beta cells;calcium imaging;glucose-dependence;network analysis;
Many details of glucose-stimulated intracellular calcium changes in [beta] cells during activation, activity, and deactivation, as well as their concentration-dependence, remain to be analyzed. Classical physiological experiments indicated that in islets, functional differences between individual ce ...
Leto: 2021 Vir: Medicinska fakulteta (UM MF)
ǂThe ǂrole of cAMP in beta cell stimulus-secretion and intercellular coupling
Andraž Stožer, Eva Paradiž, Viljem Pohorec, Jurij Dolenšek, Lidija Križančić Bombek, Marko Gosak, Maša Skelin
Pregledni znanstveni članek
Oznake: cAMP;beta cells;stimulus-secretion coupling;intercellular coupling;PKA;Epac2A;
Pancreatic beta cells secrete insulin in response to stimulation with glucose and other nutrients, and impaired insulin secretion plays a central role in development of diabetes mellitus. Pharmacological management of diabetes includes various antidiabetic drugs, including incretins. The incretin ho ...
Leto: 2021 Vir: Medicinska fakulteta (UM MF)
SNAP-25b-deficiency increases insulin secretion and changes spatiotemporal profile of Ca2+oscillations in [beta] cell networks
Teresa Daraio, Lidija Križančić Bombek, Marko Gosak, Ismael Valladolid-Acebes, Maša Skelin, Essam Refai, Per-Olof Berggren, Kerstin Brismar, Marjan Rupnik, Christina Bark
Izvirni znanstveni članek
Oznake: insulin secretion;pre-diabetes;
SNAP-25 is a protein of the core SNARE complex mediating stimulus-dependent release of insulin from pancreatic [beta] cells. The protein exists as two alternatively spliced isoforms, SNAP-25a and SNAP-25b, differing in 9 out of 206 amino acids, yet their specific roles in pancreatic [beta] cells rem ...
Leto: 2017 Vir: Medicinska fakulteta (UM MF)
Functional characteristics of hub and wave-initiator cells in [beta] cell networks
Marko Šterk, Jurij Dolenšek, Maša Skelin, Lidija Križančić Bombek, Eva Paradiž, Jasmina Kerčmar, Matjaž Perc, Marjan Rupnik, Andraž Stožer, Andraž Stožer, Marko Gosak, Marko Gosak
Izvirni znanstveni članek
Oznake: islets of Langerhans;beta cells;insulin;
Leto: 2023 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 9
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