Iskalni niz:
išči po
išči po
išči po
išči po
Vrsta gradiva:
Jezik:
Št. zadetkov: 9
Molecular dynamics-derived pharmacophore model explaining the nonselective aspect of KV10.1 pore blockers
Žan Toplak, Franci Merzel, Luis A. Pardo, Lucija Peterlin-Mašič, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: zaviralci kalijevih kanalčkov;molekularna dinamika;farmakofor;cancer;Eag1;hERG;KV10.1 inhibitors;molecular dynamics;pharmacophore;
The KV10.1 voltage-gated potassium channel is highly expressed in 70% of tumors, and thus represents a promising target for anticancer drug discovery. However, only a few ligands are known to inhibit KV10.1, and almost all also inhibit the very similar cardiac hERG channel, which can lead to undesir ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Discovery of K V 1.3 ion channel inhibitors
Špela Gubič, Louise Antonia Hendrickx, Žan Toplak, Maša Sterle, Steve Peigneur, Tihomir Tomašić, Luis A. Pardo, Jan Tytgat, Anamarija Zega, Lucija Peterlin-Mašič
Pregledni znanstveni članek
Oznake: KV1.3 channel;design of KV1.3 inhibitors;mitochondrial KV1.3;peptide inhibitors;small-molecule inhibitors;
The KV1.3 voltage gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting KV1.3 with specific peptides and small molecule inhibitors shows great potential for treatin ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
New diarylamine KV10.1 inhibitors and their anticancer potential
Špela Gubič, Žan Toplak, Xiaoyi Shi, Jaka Dernovšek, Louise Antonia Hendrickx, Ernesto Lopes Pinheiro-Junior, Steve Peigneur, Jan Tytgat, Luis A. Pardo, Lucija Peterlin-Mašič, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: KV10.1;ionski kanali;hERG;SAR;antiproliferativno delovanje;ion channels;antiproliferative activity;
Expression of the voltage-gated potassium channel KV10.1 (Eag1) has been detected in over 70% of human cancers, making the channel a promising new target for new anticancer drug discovery. A new structural class of KV10.1 inhibitors was prepared by structural optimisation and exploration of the stru ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Speaker Diarization For Multi-Microphone Meetings Using Only Between-Channel Differences
Jose Pardo
Video in druga učna gradiva
Oznake: computer science;speech analysis
Leto: 2006 Vir: videolectures.net
On the balanced upper chromatic number of cyclic projective planes and projective spaces
Gabriela Araujo-Pardo, György Kiss, Amanda Montejano
Izvirni znanstveni članek
Oznake: balanced rainbow-free colorings;upper chromatic number;projective planes;projective spaces;
On the balanced upper chromatic number of cyclic projective planes and projective spaces
Leto: 2015 Vir: Univerza na Primorskem (UP)
Automatic detection and delineation of karst terrain depressions and its application in geomorphological mapping and morphometric analysis
Peter A. Dowd, Juan José Durán Valsero, Eulogio Pardo-Igúzquiza
Izvirni znanstveni članek
Oznake: digital relief models;karst phenomena;cartography;
Leto: 2013 Vir: dLib.si Digitalna knjižnica Slovenije
Automatic detection and delineation of karst terrain depressions and its application in geomorphological mapping and morphometric analysis
Eulogio Pardo-Igúzquiza, Juan José Durán Valsero, Peter A. Dowd
Ni določena
Oznake:
Digital elevation models (DEM) are digital representations of topography that are especially suitable for numerical terrain analysis in earth sciences and engineering. One of the main quantitative uses of DEM is the automatic delineation of flow networks and watersheds in hydrology and geomorphology ...
Leto: 2013 Vir: ZRC SAZU
Automatic detection and delineation of karst terrain depressions and its application in geomorphological mapping and morphometric analysis
Eulogio Pardo-Igúzquiza, Juan José Durán Valsero, Peter A. Dowd
Izvirni znanstveni članek
Oznake:
Digital elevation models (DEM) are digital representations of topography that are especially suitable for numerical terrain analysis in earth sciences and engineering. One of the main quantitative uses of DEM is the automatic delineation of flow networks and watersheds in hydrology and geomorphology ...
Leto: 2013 Vir: ZRC SAZU
Protein activity of the fusarium fujikuroi rhodopsins CarO and OpsA and their relation to fungus-plant interaction
Alexander Adam, Stephan Deimel, Andrei Mocan, Javier Pardo-Medina, Jorge García-Martínez, Tilen Konte, M. Carmen Limón, Javier Avalos, Ulrich Terpitz
Izvirni znanstveni članek
Oznake: glivični rodopsini;aktivnost beljakovin;indol-3-ocetna kislina (IAA);fungal rhodopsins;protein activity;indole-3-acetic acid (IAA);
Fungi possess diverse photosensory proteins that allow them to perceive different light wavelengths and to adapt to changing light conditions in their environment. The biological and physiological roles of the green light-sensing rhodopsins in fungi are not yet resolved. The rice plant pathogen Fusa ...
Leto: 2018 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 9
Ključne besede:
Leto izdaje:
Avtorji:
Repozitorij:
Tipologija:
Jezik: